dc.description.abstract |
Histamine has been found to be an important component during the
exercise recovery period, particularly in mediating vasodilation,
hyperemia, and hypotension. Blocking H1/H2 histamine receptors
produced altered outcomes during recovery, including a decrease in
interstitial glucose concentrations and reductions in blood flow and
whole-body insulin sensitivity. It is unknown if blood glucose
concentrations change with histamine receptor blockades, specifically
during the exercise period. PURPOSE: To determine if H1/H2
histamine receptor blockades decrease blood glucose concentrations
during exercise. HYPOTHESIS: It was hypothesized that histamine
receptor blockade would decrease blood glucose concentrations
during exercise. METHODS: Nine competitive cyclists performed 120
minutes of cycling exercise at 50% VO2 peak. 60 minutes prior to
exercise, subjects were given either a placebo or histamine receptor
blockades (540 mg Fexofenadine and 300 mg Ranitidine). Blood
glucose concentrations were measured using a handheld Precision
Xtra Blood Glucose Monitoring System (Abbot Diabetes Care INC,
Alameda CA). Measurements were taken from the earlobe pre-exercise
and three times during exercise at 15, 60, and 120 minutes.
A repeated-measures two-way ANOVA (RM ANOVA, Group X Time)
was used for statistical analysis. RESULTS: No differences were
found between placebo and histamine receptor blockades groups (p =
0.801), and no Group X Time Interaction was determined (p = 0.881).
Blood glucose levels at 15, 60, and 105 minutes were lower than the
pre-exercise levels (p<0.001). CONCLUSION: No significant
differences in blood glucose concentrations were found between
placebo and histamine receptor blockade groups. |
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