Cioffi, CamilleBrannen, Alexa2024-08-302024-08-302024https://hdl.handle.net/1794/2988935 pagesPolysubstance use is a major public health concern, and individuals facing housing instability are at a higher risk of engaging in substance use. Traditional perceptions of homelessness often overlook the fact that individuals experiencing housing instability can engage in cohabitation or shared living arrangements. To address the unique needs of this population, it is crucial to explore how different aspects of interpersonal relationships, including gender, influence polysubstance use patterns. This study specifically investigates the use of legal substances among individuals who inject illegal drugs, providing insight into the complexities of legal and illegal substance interactions. Utilizing survey data collected from people who inject drugs throughout the COVID-19 pandemic, and analyses were conducted on gender, housing status, social living arrangement, and substance use. The findings highlight the importance of evidence-based interventions that address polysubstance use disorders among individuals facing housing instability and reveal potential underlying factors contributing to polysubstance use within this population. By addressing these factors, society can better prevent and manage polysubstance use. This study serves as an influential step toward creating long-term solutions that promote the well-being of this population.en-USCC BY-NC-ND 4.0NeurosciencePolysubstance UsePrevention ScienceSubstance UseHousing InstabilityThesis/Dissertation0009-0005-3111-0186