Raqueno-Angel, SabrinaEly, MattSieck, DylanHalliwell, John2017-10-102017-10-102017https://hdl.handle.net/1794/22813Single page poster pdf.Histamine has been found to be an important component during the exercise recovery period, particularly in mediating vasodilation, hyperemia, and hypotension. Blocking H1/H2 histamine receptors produced altered outcomes during recovery, including a decrease in interstitial glucose concentrations and reductions in blood flow and whole-body insulin sensitivity. It is unknown if blood glucose concentrations change with histamine receptor blockades, specifically during the exercise period. PURPOSE: To determine if H1/H2 histamine receptor blockades decrease blood glucose concentrations during exercise. HYPOTHESIS: It was hypothesized that histamine receptor blockade would decrease blood glucose concentrations during exercise. METHODS: Nine competitive cyclists performed 120 minutes of cycling exercise at 50% VO2 peak. 60 minutes prior to exercise, subjects were given either a placebo or histamine receptor blockades (540 mg Fexofenadine and 300 mg Ranitidine). Blood glucose concentrations were measured using a handheld Precision Xtra Blood Glucose Monitoring System (Abbot Diabetes Care INC, Alameda CA). Measurements were taken from the earlobe pre-exercise and three times during exercise at 15, 60, and 120 minutes. A repeated-measures two-way ANOVA (RM ANOVA, Group X Time) was used for statistical analysis. RESULTS: No differences were found between placebo and histamine receptor blockades groups (p = 0.801), and no Group X Time Interaction was determined (p = 0.881). Blood glucose levels at 15, 60, and 105 minutes were lower than the pre-exercise levels (p<0.001). CONCLUSION: No significant differences in blood glucose concentrations were found between placebo and histamine receptor blockade groups.enCreative Commons BY-NC-ND 4.0-USHistamineGlucoseExerciseBlood glucoseOther