Novel Interspecies Interactions of Oral Commensal Corynebacterium and Opportunistic Pathogen Candida albicans
| dc.contributor.advisor | Jens, Kreth | en_US |
| dc.contributor.author | Rozendal, T. | en_US |
| dc.date.accessioned | 2024-06-25T19:20:55Z | |
| dc.date.available | 2024-06-25T19:20:55Z | |
| dc.description | Single page poster | en_US |
| dc.description.abstract | Sophisticated synergistic and antagonistic relationships within the oral commensal community contribute to host defense against invading pathogens. Dysbiosis in the oral microbiome can lead to oral diseases and systemic health concerns. Of particular interest is the opportunistic pathogen Candida albicans and its synergistic interaction with Streptococcus mutans, which promotes virulent hyphae formation and biofilm production in C. albicans. Some fatty acids released by the oral commensal Corynebacterium species are known to inhibit Candida biofilm formation. In this study, we isolated several oral Candida strains to assess hyphae formation when co-cultured with S. mutans. Additionally, we introduced Corynebacterium durum into the co-culture in order to investigate its antagonistic effects on the Candida isolates. Our results reveal that C. durum significantly impacts the growth and hyphae formation of C. albicans, providing direct evidence of its antagonistic role in C. albicans pathogenesis. Furthermore, we isolated membrane vesicles from oral Corynebacterium samples, which appear to vary in composition depending on the strain and conditions. Further research is needed in order to elucidate the functional biochemistry of these membrane vesicles and understand their inhibitory mechanisms. | en_US |
| dc.identifier.uri | https://hdl.handle.net/1794/29590 | |
| dc.rights | Creative Commons BY-NC-ND 4.0-US | en_US |
| dc.subject | microbiology | en_US |
| dc.subject | candida albicans | en_US |
| dc.subject | streptococcus mutans | en_US |
| dc.subject | polymicrobial | en_US |
| dc.subject | caries and commensals | en_US |
| dc.title | Novel Interspecies Interactions of Oral Commensal Corynebacterium and Opportunistic Pathogen Candida albicans | en_US |