Using Kinetics to Study the Stabilization of Reactive Hydrosulfide by Supramolecular Receptors
| dc.contributor.advisor | Haley, Michael | |
| dc.contributor.advisor | Johnson, Darren | |
| dc.contributor.advisor | Pluth, Michael | |
| dc.contributor.author | Longnight, Faith | |
| dc.contributor.author | Fargher, Hazel (grad mentor) | |
| dc.contributor.author | de Faria, ThaĆs (grad mentor) | |
| dc.date.accessioned | 2021-07-27T16:51:59Z | |
| dc.date.available | 2021-07-27T16:51:59Z | |
| dc.date.issued | 2021 | |
| dc.description | 1 page. | |
| dc.description.abstract | Hydrosulfide (HS-) has numerous biological and physiological implications given its roles as the third endogenously produced gasotransmitter. However, HS- is extremely reactive making it difficult to study. In this work, we aim to analyze how the presence of stabilizing forces from a supramolecular receptor influences the kinetics of HS- in a nucleophilic aromatic substitution (SNAr) reaction within organic media. We hypothesize that the non-covalent interactions from the supramolecular receptor will stabilize and reduce the reactivity of HS-. We will use UV-Vis to monitor the reaction over time and create non-linearized plots to obtain kinetic information. This study can provide insight into how our bodies might stabilize HS- through non-covalent interactions and give us a better understanding of the behavior of this species in biological systems. | en_US |
| dc.format.mimetype | application/pdf | |
| dc.identifier.orcid | 0000-0001-9802-7751 | |
| dc.identifier.uri | https://hdl.handle.net/1794/26443 | |
| dc.language.iso | en_US | |
| dc.publisher | University of Oregon | |
| dc.rights | CC BY-NC-ND 4.0 | |
| dc.subject | Supramolecular Receptors | en_US |
| dc.subject | Hydrosulfide | en_US |
| dc.subject | Kinetics | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Reactive | en_US |
| dc.title | Using Kinetics to Study the Stabilization of Reactive Hydrosulfide by Supramolecular Receptors | |
| dc.type | Presentation |