Finding the Signal Within the Noise: Investigating the Interaction Between Histamine, Exercise, and Inflammation
Loading...
Date
2020-09-24
Authors
Mangum, Joshua
Journal Title
Journal ISSN
Volume Title
Publisher
University of Oregon
Abstract
Histamine is commonly associated with immune responses, typically involved in allergic reactions. It can be released in multiple tissues, including skeletal muscle during exercise; however, it is unknown what it is specifically about exercise that causes the release of histamine. In addition, the role of histamine in inflammatory responses implies that it may be involved in the acute post-exercise inflammatory response. Histamine’s role and context outside of exercise, such as its role in mediating sustained post-exercise vasodilation, has guided the creation and interpretation of the studies within this dissertation. This dissertation has two major aims, with multiple experiments addressing the first aim and one larger study addressing the second aim. The first aim was to determine what is the exercise “trigger” that causes the release of histamine during exercise in skeletal muscle. The data gathered from the studies within this aim suggest that increased skeletal muscle temperature, which occurs during exercise, may be the exercise trigger that is resulting in the observed increase in skeletal muscle histamine during exercise. Furthermore, data from Chapter V demonstrates there is a local factor or factors released from skeletal muscle during exercise that causes mast cells to degranulate more so than in resting conditions. Finally, the second aim sought to determine the role of histaminergic signaling in the acute post-exercise inflammatory response to aerobic exercise in untrained individuals. Our data suggests that histamine H1/H2 receptor antagonism using over-the-counter medications does not augment the systemic inflammatory response, out to 48 hours, following a novel bout of exercise in untrained individuals. While there was no effect of histamine receptor antagonism on systemic circulating inflammatory factors, future work should investigate how histamine receptor antagonism may affect inflammatory responses in skeletal muscle where histamine is formed and released. The findings of the studies within this dissertation highlight the interaction between exercise and histamine release in skeletal muscle. Further research expanding upon these findings will help to elucidate all the factors of exercise that may influence the release of histamine in skeletal muscle and the role of histaminergic signaling in the inflammatory milieu of skeletal muscle following exercise.