Development of a Nanohoop Rotaxane For Sensing Reactive Oxygen Species
| dc.contributor.advisor | Jasti, Ramesh | |
| dc.contributor.advisor | Otteson, Claire | |
| dc.contributor.author | Liao, Phyllis | |
| dc.date.accessioned | 2021-07-27T16:51:16Z | |
| dc.date.available | 2021-07-27T16:51:16Z | |
| dc.date.issued | 2021 | |
| dc.description | 1 page. | |
| dc.description.abstract | Observing biological processes such as disease progression and gene expression require elaborate probes and sensors. In biomedical research, there is interest in making a multifunctional and modular scaffold that can target specific analytes by having a system that is “triggered” by the analyte which then affords a turn-on fluorescent response. Carbon nanohoops, or [n]-cycloparaphenylenes ([n]-CPPs) are a new nanostructure that allows us to observe biological processes by incorporating it into a larger structure called a rotaxane. Inspired by this model, we developed a novel modular probe system using a boronic ester trigger to detect reactive oxygen species (ROS). We began by synthesizing the rotaxane via copper-catalyzed azide-alkyne cycloadditions (AT-CuAAC), an active template method familiar to us and has demonstrated efficiency in previous publications. Once the structure was made, we characterized and analyzed it by subjecting it to simple non-biological environments and introduced ROS to see if the turn-on fluorescence is due to dethreading of the rotaxane. Success of the system is indicated by a turn-on fluorescence when reacted with these ROS and this shows that nanohoop-based [2] rotaxanes are tailorable for use in biomedical research. | en_US |
| dc.format.mimetype | application/pdf | |
| dc.identifier.orcid | 0000-0002-9763-7504 | |
| dc.identifier.uri | https://hdl.handle.net/1794/26437 | |
| dc.language.iso | en_US | |
| dc.publisher | University of Oregon | |
| dc.rights | CC0 | |
| dc.subject | Organic chemistry | en_US |
| dc.subject | Rotaxanes | en_US |
| dc.subject | Molecular Interlocked Molecules | en_US |
| dc.subject | Cycloparaphenylenes | en_US |
| dc.subject | Reactive Oxygen Species | en_US |
| dc.title | Development of a Nanohoop Rotaxane For Sensing Reactive Oxygen Species | |
| dc.type | Presentation |