Pilot Screening to Identify Social Circuitry
| dc.contributor.advisor | Washbourne, Phil | |
| dc.contributor.author | Dawson, Matthew | |
| dc.contributor.author | Dawson, Matthew | |
| dc.contributor.author | Bruckner, Joseph | |
| dc.contributor.author | Tallafuss, Alexandra | |
| dc.contributor.author | Washbourne, Phil | |
| dc.date.accessioned | 2020-08-11T17:25:48Z | |
| dc.date.available | 2020-08-11T17:25:48Z | |
| dc.date.issued | 2020 | |
| dc.description | Project files include 1 page pdf. | |
| dc.description.sponsorship | Humans have a long history of working in social groups with a plethora of research supporting the benefits of positive human interaction. While these behaviors may seem intuitive, they can be argued as the most intricate behaviors displayed by animals. To generate a situationally relevant response to social others, an animal must be able to track dynamic systems and recall past experiences. Given the inherent multisensory nature of social behaviors, it is expected that this system can be perturbed by a multitude of neurological disorders. Using animal models, we can begin to construct the neuronal circuitry necessary for development of social behaviors. This circuitry can be used to understand social behavior deficits and may reveal possible interventions for disorders. Zebrafish, Danio rerio, perform stereotyped social behaviors, such as shoaling, which can be used to explore neuronal changes associated with deficits in performing the behavior. Through chemo-genetic ablations, we were able to cause cell death to select neurons due to variations in gene expression. Once chemically treated, fish were put into a virtual social assay that untreated zebrafish respond to. Zebrafish exhibiting decreased social response would indicate that the ablated neurons are necessary for social behavior. | |
| dc.format.mimetype | Dawson_Matthew_2020urs.mp4 | |
| dc.format.mimetype | Dawson_Matthew_2020urs.pdf | |
| dc.identifier.orcid | CC0 | |
| dc.identifier.uri | https://hdl.handle.net/1794/25451 | |
| dc.language.iso | en_US | |
| dc.publisher | University of Oregon | |
| dc.rights | Creative Commons McNair Scholars | |
| dc.subject | social behavior | en_US |
| dc.subject | circuitry | en_US |
| dc.subject | neurons | en_US |
| dc.subject | zebrafish | en_US |
| dc.title | Pilot Screening to Identify Social Circuitry | |
| dc.type | Presentation |