Development of a Synthetic Supramolecular Receptor for the Hydrosulfide Anion

dc.contributor.authorPrakel, Samuel Scott
dc.date.accessioned2018-12-15T17:18:38Z
dc.date.available2018-12-15T17:18:38Z
dc.date.issued2018-03
dc.description44 pages. Presented to the Department of Chemistry and Biochemistry and the Robert D. Clark Honors College in partial fulfillment of the requirements for the degree of Bachelor of Science March 2018
dc.description.abstractHydrogen sulfide (H2S) has recently emerged as an important biomolecule in cellular signaling. As its significance in various physiological processes in the cardiovascular, digestive, nervous, and immune systems is still being uncovered, reversible detection techniques for H2S and its predominant form, hydrosulfide (HS–), are necessary to properly research the binding and activity of this gasotransmitter. This thesis reports the first synthetic receptor capable of reversibly binding HS–. In addition to hydrogen bonding from urea NH groups to HS–, this receptor also uses a notable aromatic CH---S hydrogen bond to achieve binding constants of up to 90,300 ± 8700 M–1 in acetonitrile. This fundamental study should pioneer work toward developing new, synthetic HS– receptors and increase the understanding of biological HS– receptors and synthetic H2S recognition techniques.en_US
dc.identifier.urihttps://hdl.handle.net/1794/24069
dc.language.isoen_US
dc.publisherUniversity of Oregon
dc.rightsCreative Commons BY-NC-ND 4.0-US
dc.subjectChemistryen_US
dc.subjectHydrogen sulfideen_US
dc.subjectSupramolecular chemistryen_US
dc.subjectBiochemistryen_US
dc.subjectAvion bindingen_US
dc.subjectUV-visen_US
dc.subjectOrganic chemistryen_US
dc.titleDevelopment of a Synthetic Supramolecular Receptor for the Hydrosulfide Anion
dc.typeThesis/Dissertation

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