Evolution of Independent Genetic Pathways for Pathogen Resistance within the Nematode Caenorhabditis remanei

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dc.contributor.advisorGuillemin, Karenen_US
dc.contributor.authorArcher, Heatheren_US
dc.date.accessioned2013-10-10T23:20:18Z
dc.date.available2013-10-10T23:20:18Z
dc.date.issued2013-10-10
dc.description.abstractPathogenic host-microbe interactions can result from continuous evolution of a host's ability to resist infection and a pathogen's ability to survive and replicate. Pseudomonas aeruginosa is a versatile and opportunistic pathogen, ubiquitous in soil, and capable of damaging plants, vertebrates, and invertebrates. Previous studies in nematodes suggest that the pathogenic effects of P. aeruginosa can result from multiple distinct pathways: a toxin-based effect that kills within a few hours and a generalized virulence that kills over the course of multiple days. Using experimental evolution in the highly polymorphic nematode Caenorhabditis remanei, I show that nematode resistance to the two modes of pathogenesis in P. aeruginosa evolves through genetically independent pathways. These results demonstrate that multiple virulence factors in a pathogen can result in multiple responses in the host, and the genetic lines established here create resources for further exploration of the genetic basis for resistance to P. aeruginosa.en_US
dc.identifier.urihttps://hdl.handle.net/1794/13438
dc.language.isoen_USen_US
dc.publisherUniversity of Oregonen_US
dc.rightsAll Rights Reserved.en_US
dc.subjectCaenorhabditisen_US
dc.subjectEvolutionen_US
dc.subjectGeneticen_US
dc.subjectImmuneen_US
dc.subjectPathogensen_US
dc.subjectPseudomonasen_US
dc.titleEvolution of Independent Genetic Pathways for Pathogen Resistance within the Nematode Caenorhabditis remaneien_US
dc.typeElectronic Thesis or Dissertationen_US
thesis.degree.disciplineDepartment of Biologyen_US
thesis.degree.grantorUniversity of Oregonen_US
thesis.degree.levelmastersen_US
thesis.degree.nameM.S.en_US

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