The Relationship Between Acute Mountain Sickness, Patent Foramen Ovale, and Systemic Inflammation

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dc.contributor.advisorDiMarco, Kaitlyn
dc.contributor.authorShah, Karina
dc.contributor.authorDiMarco, Kaitlyn
dc.contributor.authorLovering, Andrew
dc.date.accessioned2020-08-11T17:35:47Z
dc.date.available2020-08-11T17:35:47Z
dc.date.issued2020
dc.descriptionProject files are comprised of 1 page pdf and presentation recording in mp4 format.
dc.description.abstractAcute mountain sickness (AMS) occurs when individuals rapidly ascend to high altitude, but its exact cause is unknown. A patent foramen ovale (PFO) is a hole in the heart present in one-third of the population. PFO+ subjects have greater AMS incidence, but the reasons are unknown. AMS is associated with systemic inflammation as determined by elevated cytokines and data from our lab suggests that PFO+ subjects have greater systemic inflammation. Thus, we hypothesized that the association between AMS and PFO is explained by increased inflammation. To test this, 17 PFO+ subjects (9 women) and 17 PFO- subjects (9 women) were exposed to 10 hours of hypoxia simulating 15600 feet and AMS was assessed using the Lake Louise Questionnaire. Blood samples taken before and at 10 hours of hypoxia were assayed for 13 inflammatory mediators. We found that 83% of PFO+ subjects but only 61% of PFO- subjects got AMS. AMS- subjects had significantly higher levels of IL-12p70 at 10 hours than AMS+ subjects. All other cytokines had significant time effects, and the greatest increases were in AMS- subjects. Compared to PFO- subjects, PFO+ subjects had significantly higher IL-1β, interferon (IFN)-ɑ2, IL-8, IL-10, and MCP-1 levels before and at 10 hours. PFO+ subjects had the greatest increases in IFN-2, MCP-1, and IL-10 and PFO- subjects had the greatest increases in IL-10 and IL-6. These data suggest inflammation levels differ with PFO and AMS, but with separate patterns. Therefore, systemic inflammation in AMS and PFO may be more complex than previously thought.en_US
dc.description.sponsorshipDefense Medical Research & Development Program, DoD W81XWH-10-2-0114
dc.format.mimetypevideo/mp4
dc.format.mimetypeapplication/pdf
dc.identifier.orcidhttps://orcid.org/0000-0002-6107-7584
dc.identifier.urihttps://hdl.handle.net/1794/25521
dc.language.isoen_US
dc.publisherUniversity of Oregon
dc.rightsCreative Commons CC BY-NC-ND 4.0
dc.subjectacute mountain sicknessen_US
dc.subjectpatent foramen ovaleen_US
dc.subjectinflammationen_US
dc.subjectAMSen_US
dc.subjectPFOen_US
dc.titleThe Relationship Between Acute Mountain Sickness, Patent Foramen Ovale, and Systemic Inflammation
dc.typePresentation

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