Propagating Putative Prion States in Budding Yeast
dc.contributor.advisor | Garcia, David | |
dc.contributor.author | Evarts, Jacob | |
dc.contributor.author | Garcia, David | |
dc.date.accessioned | 2020-08-11T17:26:27Z | |
dc.date.available | 2020-08-11T17:26:27Z | |
dc.date.issued | 2020 | |
dc.description | Project files are comprised of 1 page pdf and presentation recording in mp4 format. | |
dc.description.abstract | Prions have long been closely associated with fatal neurodegenerative diseases. Recent evidence suggests that prions provide an additional class of epigenetic mechanism that works at a rapid pace. From an evolutionary standpoint, the ability to change phenotypes without waiting for a genetic variance would be hugely beneficial in a high-stress environment. Using two known techniques for increasing de novo prion formation, protein overexpression, and environmental stressor, the Garcia Lab performed a large-scale screen across many RNA modifying enzymes in budding yeast. The initial analysis of the resulting growth curves suggests that putative prion-state induction could be a widespread epigenetic mechanism across yeast. | en_US |
dc.description.sponsorship | VPRI Fellowship | |
dc.format.mimetype | video/mp4 | |
dc.format.mimetype | application/pdf | |
dc.identifier.orcid | 0000-0002-6048-3310 | |
dc.identifier.uri | https://hdl.handle.net/1794/25456 | |
dc.language.iso | en_US | |
dc.publisher | University of Oregon | |
dc.rights | Creative Commons CC0 | |
dc.subject | Budding Yeast | en_US |
dc.subject | Prions | en_US |
dc.subject | RNA | en_US |
dc.subject | Proteins | en_US |
dc.subject | Computational Biology | en_US |
dc.title | Propagating Putative Prion States in Budding Yeast | |
dc.type | Presentation |