Propagating Putative Prion States in Budding Yeast

dc.contributor.advisorGarcia, David
dc.contributor.authorEvarts, Jacob
dc.contributor.authorGarcia, David
dc.date.accessioned2020-08-11T17:26:27Z
dc.date.available2020-08-11T17:26:27Z
dc.date.issued2020
dc.descriptionProject files are comprised of 1 page pdf and presentation recording in mp4 format.
dc.description.abstractPrions have long been closely associated with fatal neurodegenerative diseases. Recent evidence suggests that prions provide an additional class of epigenetic mechanism that works at a rapid pace. From an evolutionary standpoint, the ability to change phenotypes without waiting for a genetic variance would be hugely beneficial in a high-stress environment. Using two known techniques for increasing de novo prion formation, protein overexpression, and environmental stressor, the Garcia Lab performed a large-scale screen across many RNA modifying enzymes in budding yeast. The initial analysis of the resulting growth curves suggests that putative prion-state induction could be a widespread epigenetic mechanism across yeast.en_US
dc.description.sponsorshipVPRI Fellowship
dc.format.mimetypevideo/mp4
dc.format.mimetypeapplication/pdf
dc.identifier.orcid0000-0002-6048-3310
dc.identifier.urihttps://hdl.handle.net/1794/25456
dc.language.isoen_US
dc.publisherUniversity of Oregon
dc.rightsCreative Commons CC0
dc.subjectBudding Yeasten_US
dc.subjectPrionsen_US
dc.subjectRNAen_US
dc.subjectProteinsen_US
dc.subjectComputational Biologyen_US
dc.titlePropagating Putative Prion States in Budding Yeast
dc.typePresentation

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