An Actin Cross-Linking Effector of the Vibrio Type Six Secretion System Increases Intestinal Motility Through Macrophage Redistribution
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Date
2024-03-25
Authors
Ngo, Julia
Journal Title
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Publisher
University of Oregon
Abstract
Host-microbe interactions within the gastrointestinal tract have long been recognized as pivotal for maintaining physiological balance. However, the intricate mechanisms underlying these interactions remain enigmatic. This study delves into the complex world of host-microbe relationships, focusing on the Vibrio type VI secretion system (T6SS), particularly the actin cross-linking domain (ACD) of the valine-glycine repeat G (VgrG-1) protein. We explore the role of the ACD in altering intestinal motility in larval zebrafish. Our findings reveal a fascinating mechanism underlying these interactions. Vibrio, known for its pathogenic potential, instigates cellular death and tissue damage within the vent region of the zebrafish intestine. This destructive action triggers an immune response within macrophages from their typical habitat in the midgut to the affected vent region.
This revelation emphasizes the disruptive influence of bacterial pathogenesis on macrophages and, by extension, their role in regulating intestinal motility. Our findings provide valuable insights into the intricacies of intestinal motility regulation in the context of host-microbe interactions.
In conclusion, this research broadens our understanding of the mechanism by which gut microbes influence host physiology, specifically in the context of intestinal motility. The presence of bacterial pathogenesis and its influence on macrophages, coupled with insights into the intricate dynamics of host-microbe interactions, underscores the significance of this work. This intricate interplay between microbes and host systems not only reveals microbial influences on host physiology but also highlights the mechanisms employed by the host to maintain homeostasis.