Effects of histamine-receptor blockade and exercise on blood-glucose concentration
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Date
2017
Authors
Raqueno-Angel, Sabrina
Ely, Matt
Sieck, Dylan
Halliwell, John
Journal Title
Journal ISSN
Volume Title
Publisher
University of Oregon
Abstract
Histamine has been found to be an important component during the
exercise recovery period, particularly in mediating vasodilation,
hyperemia, and hypotension. Blocking H1/H2 histamine receptors
produced altered outcomes during recovery, including a decrease in
interstitial glucose concentrations and reductions in blood flow and
whole-body insulin sensitivity. It is unknown if blood glucose
concentrations change with histamine receptor blockades, specifically
during the exercise period. PURPOSE: To determine if H1/H2
histamine receptor blockades decrease blood glucose concentrations
during exercise. HYPOTHESIS: It was hypothesized that histamine
receptor blockade would decrease blood glucose concentrations
during exercise. METHODS: Nine competitive cyclists performed 120
minutes of cycling exercise at 50% VO2 peak. 60 minutes prior to
exercise, subjects were given either a placebo or histamine receptor
blockades (540 mg Fexofenadine and 300 mg Ranitidine). Blood
glucose concentrations were measured using a handheld Precision
Xtra Blood Glucose Monitoring System (Abbot Diabetes Care INC,
Alameda CA). Measurements were taken from the earlobe pre-exercise
and three times during exercise at 15, 60, and 120 minutes.
A repeated-measures two-way ANOVA (RM ANOVA, Group X Time)
was used for statistical analysis. RESULTS: No differences were
found between placebo and histamine receptor blockades groups (p =
0.801), and no Group X Time Interaction was determined (p = 0.881).
Blood glucose levels at 15, 60, and 105 minutes were lower than the
pre-exercise levels (p<0.001). CONCLUSION: No significant
differences in blood glucose concentrations were found between
placebo and histamine receptor blockade groups.
Description
Single page poster pdf.
Keywords
Histamine, Glucose, Exercise, Blood glucose