Differential Functional Connectivity of Anterior and Posterior Hippocampus
Trevor Bissert, Lea E. Frank, Dasa Zeithamova
Introduction Methods
Measures of Memory Specificity
The Hippocampus aids in linking and remembering • Individuals Completed Several Measures of Memory Measures of Memory Generalization Study:- 60 images of animals and tools
experiences, forming general representations of the Specificity and Generalization Study: Test:
world o Example tasks on the right +Which family? Which family? + +
Correct! 2 s
He is a Miller. Test: 3 s
Measuring Functional Connectivity + 2 s 3 sMiller Wilson Dis - 60 old items and 60 related lures
4 s Miller  Wilson Davis
1 s
1 s
Posterior Hippocampus Study: +1: old 2: new +
Research suggests functional specialization between Anterior Hippocampus self-paced 1: old 2: new1 s self-paced
1 s 1: old 2: new 
posterior and anterior hippocampus 1 Study: self-paced+
• Posterior à Specific memories 150 IFG 4 s College  +  Blessing
• Anterior à Generalized memories 100 AHIP 1 s Friend + LoyaltyTest: 4 s Food + Money
50
4 s
Mission: to see if anterior and posterior hippocampal 0 Test: 1 s 4 s
-50
connections differentially support memory 
-100 Indirect Associations Direct Associations
generalization and memory specificity College  + ________ Friend + _______ Food + ________ -150
Time (5 mins)
Preliminary Results (N=28) Conclusions
Predictions • Posterior and anterior hippocampal regions 
• Anterior and posterior hippocampus will be connected IFG (ant) form distinct functional connections with 
to distinct brain regions
• Anterior hippocampal connections will be associated very little overlap
Temporal Pole (post)
with memory generalization PHIP • Predictions not confirm` ed as both anterior 
• Posterior hippocampal connections will be associated AHIP and posterior hippocampal connections 
with memory specificity predicted generalization
• No connections predicted memory 
Whole Brain Connectivity specificity
Analysis Temporal Pole (ant)
PHIP Connections That Predict Generalization Success References & Acknowledgements
AHIP • Many connections of both anterior and posterior hippocampus predicted 1  Frank, L. E., Bowman, C. R., & Zeithamova, D. (2019). Differential Functional Connectivity 
OVERLAP generalization *key connections included along the Long Axis of the Hippocampus Aligns with Differential Role in Memory Specificity and Generalization. Journal of cognitive neuroscience, 31(12), 1958–1975. 
o Posterior – Temporal Pole*, Superior Frontal Gyrus, Middle Frontal Gyrus https://doi.org/10.1162/jocn_a_01457
o Anterior – Temporal Pole*, Inferior Frontal Gyrus*, Paracingulate Gyrus, Juxtapositional 
Poppenk, J., Evensmoen, H. R., Moscovitch, M., & Nadel, L. (2013). Long-axis specialization 
Lobule cortex, Supramarginal Gyrus of the human hippocampus. Trends in Cognitive Sciences,17(5), 230-240. 
• No connections reliably predicted memory specificity doi:10.1016/j.tics.2013.03.005
Mean Signal
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