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oai:scholarsbank.uoregon.edu:1794/313832025-09-10T20:50:58Zcom_1794_7557com_1794_7555com_1794_7552col_1794_169

Hosseinzadeh, Parisa Stokes, Hanna 2025-07-29T22:50:32Z 2025 https://hdl.handle.net/1794/31383 0009-0008-6562-972X 31 pages Cell-penetrating cyclic peptides (CPPs) are a promising tool in the delivery of therapeutic drugs to cells1 and can act as therapeutics themselves. These therapeutic agents are aimed at the treatment of diseases such as HIV, cancer, and multidrug-resistant bacterial diseases. Their large surface area and higher conformational rigidity and stability relative to their linear counterparts2 potentiate them to have a higher affinity and specificity for any target of interest. Additionally, CPPs have higher resistance to degradation, unlike their linear counterparts. Thus, for innovative developments in the peptide therapeutics field, it is paramount to have tools for studying and accelerating the discovery of CPPs. In this project, we aim to unravel the underlying rules of cell permeation of cyclic peptides and develop novel high-throughput methods for screening their cell penetration. Additionally, we aim to develop computational methods to predict the permeability of cyclic peptides based on their sequence. Targeting specific organelles can mitigate side effects and toxicity of the drug to cells. Understanding the core features of cell-penetrating peptides will allow for great advancements in therapeutics and the development of less invasive oral bioavailable treatments. en_US University of Oregon CC BY-NC-ND 4.0 Peptide Antimicrobial High-throughput Cyclic Cellular Uptake High-Throughput Cell Penetration Assay for the Discovery of Cell Penetrating Cyclic Peptides Dissertation or thesisopen.access