Browsing by Author "Wagner, Andrew"

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Discovery and Characterization of WISH/DIP/SPIN90 Proteins as a Class of ARP2/3 Complex Activators that Function to Seed Branched Actin Networks

Wagner, Andrew (University of Oregon, 2018-04-10)

Assembly of branched actin filaments produces dynamic structures required during membrane associated processes including cell motility and endocytosis. The Actin Related Protein 2/3 (Arp2/3) complex is the only known ...
Investigating the role of NPFs in the Arp3ΔC phenotype

Kiemel, Jonathan; Rodnick-Smith, Max; Liu, Su-Ling; Nolen, Brad; Wagner, Andrew

The Arp2/3 complex is an assembly of seven protein subunits that nucleates branched actin networks involved in cellular functions such as endocytosis. Previous work has determined the complex is intrinsically inactive, and ...