Browsing by Author "Bowerman, Bruce"

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The Construction and Deconstruction of Signaling Systems that Regulate Mitotic Spindle Positioning

Lu, Michelle (University of Oregon, 2013-07-11)

Signaling systems regulate the flow of cellular information by organizing proteins in space and time to coordinate a variety of cellular activities that are critical for the proper development, function, and maintenance ...
Control of Histone H3 Lysine 27 Trimethylation in Neurospora crassa

Jamieson, Kirsty (University of Oregon, 2015-01-14)

Trimethylation of histone H3 lysine 27 (H3K27me3) marks facultative heterochromatin, containing silent genes. My research investigated factors that influence the distribution of H3K27me3 in the filamentous fungus Neurospora ...
Drosophila Embryonic Type II Neuroblasts: Origin, Temporal Patterning and Contribution to the Adult Central Complex

Walsh, Kathleen (University of Oregon, 2018-04-10)

The large numbers of neurons that comprise the adult brain display an immense diversity. Repeated divisions of a relatively small pool of neural stem cells generate this neuronal diversity during development. To increase ...
Excess crossovers impede faithful meiotic chromosome segregation in C. elegans

Hollis, Jeremy A.; Glover, Marissa L.; Schlientz, Aleesa J.; Cahoon, Cori K.; Bowerman, Bruce; Wignall, Sarah M.; Libuda, Diana E. (Public Library of Science, 2020-09-04)

During meiosis, diploid organisms reduce their chromosome number by half to generate haploid gametes. This process depends on the repair of double strand DNA breaks as crossover recombination events between homologous ...
Massively Parallel Sequencing-Based Analyses of Genome and Protein Function

Kamps-Hughes, Nicholas (University of Oregon, 2015-08-18)

The advent of high-throughput DNA and RNA sequencing has made possible the assay of millions of nucleic acid molecules in parallel. This allows functional genomic elements to be identified from background in single-tube ...
Mechanisms of Branched Actin Network Formation through Coordinate Activation of Arp2/3 Complex

Helgeson, Luke (University of Oregon, 2015-01-14)

Fundamental cellular processes such as motility and endocytosis rely on the actin cytoskeleton to translate biochemical protein interactions into mechanical forces. Cells utilize an extensive collection of actin binding ...
Oocyte Meiotic Cell Division: Spindle Assembly, Chromosome Segregation, and Cytokinesis.

Schlientz, Aleesa (University of Oregon, 2020-09-24)

Meiosis, the specialized cell division process that results in haploid gamete formation, is characterized by a single round of genome duplication followed by two successive divisions. During meiosis, replicated homologous ...
Spatial Regulation of the Polarity Protein aPKC During Asymmetric Cell Division of Drosophila Neuroblasts

Drummond, Mike (University of Oregon, 2015-08-18)

The Par complex protein, atypical protein kinase C (aPKC), plays an instrumental role in diverse cell polarities. aPKC is able to restrict substrate localization through a phosphorylation-induced cortical exclusion ...
Temporal Patterning and Generation of Neural Diversity in Drosophila Type II Neuroblast Lineages

Bayraktar, Omer (University of Oregon, 2013-10-03)

The central nervous system (CNS) has an astonishing diversity of neurons and glia. The diversity of cell types in the CNS has greatly increased throughout evolution and underlies our unique cognitive abilities. The diverse ...
XMAP215/ZYG-9 and TACC/TAC-1 Promote Bipolar Spindle Assembly and Stability during C. elegans Oocyte Meiotic Cell Division

Harvey, Austin (University of Oregon, 2022-10-26)

Despite lacking canonical, centriole-containing microtubule organizing centers, oocytes can still organize microtubules into a bipolar spindle and accurately separate chromosomes. How oocyte acentrosomal spindles achieve ...