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Browsing Chemistry Theses and Dissertations by Title
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Now showing items 1-20 of 274
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(University of Oregon, 2015-08-18)The compound cisplatin and related FDA-approved Pt(II) therapeutics have been used ubiquitously to treat a variety of cancers since the late 1970’s. Despite the success of Pt therapeutics, their use is limited by undesirable ...
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(University of Oregon, 2015-08-18)This dissertation provides a brief introduction into scanning tunneling microscopy, and then Chapter III reports on the design and operation of a cryogenic ultra-high vacuum scanning tunneling microscope (STM) coupled to ...
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(University of Oregon, 2020-02-27)Nanoparticles have garnered much interest over the past 30 years due to their unique size-dependent properties. The majority of research initially focused on developing synthetic methods to produce uniform materials with ...
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(University of Oregon, 2021-09-13)Encoded within DNA are all the instructions that a cell needs to survive, and these instructions must be regulated such that cells take the appropriate actions in response to environmental and developmental cues. One way ...
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(University of Oregon, 2016-11-21)Despite their ubiquitous use, Pt(II) anti-cancer drugs still suffer from many issues such as off-drug target effects, renal and nephrotoxicity as well as acquired and intrinsic drug resistance. To obtain a better understanding ...
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(University of Oregon, 2014-06-17)The phosphorylation activity of protein kinases is involved in virtually all biological processes of living organisms. As uncontrolled kinase cascades cause devastating defects such as cancer, cells employ complex regulatory ...
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(University of Oregon, 2021-09-13)Pathogens and parasites have evolved effective strategies to gain access to host resources. The immune system fends off these attacks, often through detection of pathogen associated molecules and clearance of infection. ...
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(University of Oregon, 2015-08-18)Inorganic nanoscale clusters have garnered significant interest for many practical applications within the fields of materials chemistry, inorganic chemistry, geochemistry, and environmental chemistry. However, the fundamental ...
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(University of Oregon, 2016-02-23)Bidentate ligands are a commonly used class of ligands in catalysis that generate highly-active and selective catalysts. Such bidentate ligands, however, often suffer from synthetic challenges, which can be alleviated by ...
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(University of Oregon, 2024-01-09)Water electrolyzers (WEs) are a key technology for a sustainable economy. When powered by renewable electricity, WEs produce green hydrogen, which can be used for energy, fertilizer, and industrial applications and thus ...
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(University of Oregon, 2018-04-10)Metal oxide thin films serve as critical components in many modern technologies, including microelectronic devices. Industrial state-of-the-art production utilizes vapor-phase techniques to make high-quality (dense, smooth, ...
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(University of Oregon, 2022-10-26)Anions are a ubiquitous class of molecule which play critical roles in many of the environments with which humans concern themselves. From our physiology to nuclear waste to our water supply, anions have been the focus of ...
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(University of Oregon, 2008-06)More than two-thirds of all enzyme substrates and cofactors are anionic, emphasizing the essential role that anions play in biological processes. Moreover, anions can have detrimental effects on the environment by causing ...
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(University of Oregon, 2011-06)Muscleblind-like 1 (MBNL1) is a splicing factor whose improper cellular localization is a central component of myotonic dystrophy (DM). In DM, the lack of properly localized MBNL1 leads to mis-splicing of many pre-mRNAs. ...
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(University of Oregon, 2010-09)Protein-protein interaction networks translate environmental inputs into specific physiological outputs. The signaling proteins in these networks require regulatory mechanisms to ensure proper molecular function. Two common ...
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(University of Oregon, 2019-01-11)Supramolecular chemistry (chemistry beyond the molecule) is the study and synthesis of complex molecular architectures from simple subunits using non-covalent interactions. The types of non-covalent interactions that are ...
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(University of Oregon, 2017-05-01)Hydrogen Sulfide (H2S) is an important biologically produced gasotransmitter along with carbon monoxide (CO) and nitric oxide (NO). Unlike CO and NO, the bioinorganic chemistry of H2S reactivity with biologically relevant ...
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(University of Oregon, 2011-09)Chemists have long recognized the potential of the BN bond to mimic CC double bonds in aromatic systems. Phenyl and indole are two of the most important arenes in natural systems, as well as medicine, applied chemistry, ...
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(University of Oregon, 2014-06-17)Cis-diamminedichloroplatinum (II), or cisplatin, is a widely prescribed anticancer compound, currently one of only three platinum (II) complexes FDA approved for cancer treatment. Despite its widespread use, we lack a ...
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(University of Oregon, 2015-08-18)Helicobacter pylori is a human pathogen that colonizes the stomach and increases the risk of diseases such as ulcers and gastric cancer. The distribution of H. pylori within the stomach is associated with different disease ...
Now showing items 1-20 of 274