Odor Concentration Change Sensing
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Mice rely on their sense of smell for spatial navigation in their environment. Navigation with regards to smell relies on using odor concentrations to home in on an odor source of interest. Olfactory neuron populations exist that are sensitive to changes in odor concentration. However, the olfactory sensory processing that mediate this behavior in mice is not fully understood yet. The overall goal is to understand how the brain tracks changes in stimuli. We focus on how the olfactory system processes change in odor concentration. Our paradigm involves the use of trained head-fixed mice. The use of head-fixed mice allows for precise control over the odor stimuli. Our equipment allows me to present a concentration of odor directly when a mouse inhales. This allows me to manipulate the concentration of odor to which the mice will be exposed between various sniff cycles. Using a behavioral paradigm, I will test how sensitive mice are to detecting a change in odor concentration. This behavioral task will demonstrate how mice track stimulus changes over time and will lay the groundwork for determining how perception relates to neural activity.