Memory Consolidation.
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Date
2021-11-23
Authors
Shofner, Steven
Journal Title
Journal ISSN
Volume Title
Publisher
University of Oregon
Abstract
This proposal synthesizes the work of other researchers (Hawkins et al. 2019) (Kim, Gulati, and Ganguly 2019) (Wei et al. 2018) (Tononi and Cirelli 2006) (Grossberg 2013) (Li et al. 2017) into a framework of memory consolidation by temporally ordered progression through sleep stages.Drawing on the memory model of (Hawkins et al. 2019), wherein cortical columns receive limbifugal predictions and learn a decomposition into individual sequential expectations learned by recruiting newly developed synapses to dendrites of pyramidal cells that receive lateral input from nearby neurons which modulate the depolarization of the cell in order to allow neurons associated with the expectation to fire first. During sleep, the weights of these newly recruited neurons are adjusted ensuring salient memories are preserved and integrated with preexistent memories.
If sleep participates in memory consolidation as outlined, all stages of sleep must be essential to the successful consolidation and integration of new memories.
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Keywords
Consolidation, Dilation, Erosion, Memory, Morphological, Sleep