Developing a Non-Invasive Compressive Load Osteoarthritis Model
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Date
2022-03
Authors
Heinonen, Jake Eric
Journal Title
Journal ISSN
Volume Title
Publisher
University of Oregon
Abstract
Osteoarthritis is a disease that impacts millions of people's lives worldwide. A significant amount of research has been directed toward studying osteoarthritis, specifically post-traumatic osteoarthritis. The research model that is most common to study post-traumatic osteoarthritis is by performing a medial meniscus transection (MMT) on a rat. This research looks at a less common, meaningful way of examining post-traumatic osteoarthritis in rats through a non-invasive compressive load knee model (NIKI). Over two years, a non-invasive compressive load model for rats has been built at the University of Oregon in the Guldberg lab. The concept of how the device would look was formed with input from the Sharma lab, and the device was built. Following the creation of the device, the circuitry was figured out with assistance from the Ong lab. Once the machine was running, spring testing calibration/validation was done. The device was calibrated and validated to ensure that voltage inputs would output the correct loads imparted to the knee joint. Once the device was calibrated, rat cadaver testing was done until ACL rupture was confirmed on a cadaver. The implications of the machine working are that the ACL rupture model may provide more relevance to actual knee injuries compared to surgically inducing a mechanical instability. The NIKI device could produce different structural and biochemical responses compared to surgical models.
Description
24 pages
Keywords
non-invasive, osteoarthritis, bioengeneering, calibration