Kaneko, K.; Peretz, David; Pan, K. K.; Blochberger, Thomas C.; Wille, H.; Gabizon, R.; Griffith, O. H.; Cohen, F. E.; Baldwin, Michael A.; Prusiner, Stanley B.
(Proceedings of the National Academy of Sciences, 1995-11)
Conversion of the cellular isoform of prion
protein (PrPc) into the scrapie isoform (PrPSc) involves an
increase in the /3-sheet content, diminished solubility, and
resistance to proteolytic digestion. Transgenetic ...
