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Browsing Chemistry and Biochemistry Faculty Works by Author "Cohen, F. E."

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  • Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform 
    Kaneko, K.; Peretz, David; Pan, K. K.; Blochberger, Thomas C.; Wille, H.; Gabizon, R.; Griffith, O. H.; Cohen, F. E.; Baldwin, Michael A.; Prusiner, Stanley B. (Proceedings of the National Academy of Sciences, 1995-11)
    Conversion of the cellular isoform of prion protein (PrPc) into the scrapie isoform (PrPSc) involves an increase in the /3-sheet content, diminished solubility, and resistance to proteolytic digestion. Transgenetic ...

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