Do Fatiguing Muscle Contractions Alter Inherent Contractile Performance in the Single Fiber?
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Date
2021
Authors
Go, George
Journal Title
Journal ISSN
Volume Title
Publisher
University of Oregon
Abstract
The increased fatiguability of muscle in older adults is recognized as a major decrement to quality-of-life accompanying age. The mechanisms by which this increased fatiguability occurs is not well understood. Research has shown that accumulating metabolites play a role in stopping optimal interaction of muscle filaments when contracting. However, older adults exhibit higher resistance to fatigue at low-velocity contractions than younger adults and fatigue more during high velocity contractions, a phenomenon that is not easily explained by accumulating metabolite levels. This study will evaluate the contractile changes in single muscle fibers that accompany fatigue, outside the influence of intracellular metabolites. Therefore, this study will explore the novel hypothesis that inherent changes in muscle cellular function, and not only intracellular metabolic environment per se, contribute to in vivo fatigue.
Description
25 pages
Keywords
muscle, cells, biology, physiology