Do Fatiguing Muscle Contractions Alter Inherent Contractile Performance in the Single Fiber?  

dc.contributor.advisorCallahan, Damien
dc.contributor.advisorRicci, Austin
dc.contributor.advisorHopkins, Samantha
dc.contributor.authorGo, George
dc.date.accessioned2021-07-27T18:46:31Z
dc.date.available2021-07-27T18:46:31Z
dc.date.issued2021
dc.description25 pages
dc.description.abstractThe increased fatiguability of muscle in older adults is recognized as a major decrement to quality-of-life accompanying age. The mechanisms by which this increased fatiguability occurs is not well understood. Research has shown that accumulating metabolites play a role in stopping optimal interaction of muscle filaments when contracting. However, older adults exhibit higher resistance to fatigue at low-velocity contractions than younger adults and fatigue more during high velocity contractions, a phenomenon that is not easily explained by accumulating metabolite levels. This study will evaluate the contractile changes in single muscle fibers that accompany fatigue, outside the influence of intracellular metabolites. Therefore, this study will explore the novel hypothesis that inherent changes in muscle cellular function, and not only intracellular metabolic environment per se, contribute to in vivo fatigue.en_US
dc.identifier.orcid0000-0003-3293-3035
dc.identifier.urihttps://hdl.handle.net/1794/26521
dc.language.isoen_US
dc.publisherUniversity of Oregon
dc.rightsCC BY-NC-ND 4.0
dc.subjectmuscleen_US
dc.subjectcellsen_US
dc.subjectbiologyen_US
dc.subjectphysiologyen_US
dc.titleDo Fatiguing Muscle Contractions Alter Inherent Contractile Performance in the Single Fiber?  
dc.typeThesis/Dissertation

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