Language Mapping with Dense Array EEG Source Localization: Implications for Neurosurgical Planning

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Title: Language Mapping with Dense Array EEG Source Localization: Implications for Neurosurgical Planning
Author: Nelson, Joseph
Abstract: Current language mapping protocols for neurosurgical planning are invasive, expensive, and not suitable for all surgical candidates. We investigated the potential of dense array EEG to determine hemispheric dominance for language and localize current sources of semantic and lower level language functions in the brain using a semantic decision task, a phonological decision task, and an acoustic decision task. Source estimates of N400-window ERPs (N365, N480) and the Late Positive Complex (LPC) localized strongly to medial temporal regions. Overall source estimates revealed a slight left lateralized network, with more posterior engagement for the semantic condition and more anterior engagement for the phonological condition. Source localization of the resulting t-test wave from the semantic - phonological highlighted a stronger left lateralized pattern of activation encompassing more of the semantic network. As a first pass these results are promising, but need to be investigated on individual subject ERPs.
URI: http://hdl.handle.net/1794/12464
Date: 2012


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