Identifying Genes Required for Cell Division in the Early C. elegans Embryo
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Date
2013-11
Authors
Standage, Hayley
Journal Title
Journal ISSN
Volume Title
Publisher
University of Oregon
Abstract
The oocyte meiotic spindle and the mitotic spindle are necessary to proper
cell division and subsequent development of the zygote. The spindle facilitates
chromosome segregation to properly distribute genetic information to newly
formed daughter cells. Four C. elegans temperature-sensitive mutants are
examined in this paper that have defects in spindle formation or function. or1592
and or854 have defective oocyte meiotic spindles, while or1269 and or987 have
dysfunctional mitotic spindles. Analysis of these mutants suggests each may be a
novel allele of a gene essential to early embryonic development. Further study of
these mutants will be carried out to identify the mutation and characterize their
specific role in the spindle throughout cell division.
Description
42 pages. A thesis presented to the Department of Biology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Fall 2013.
Keywords
Biology, Genes, Cell division, Early embryo, C. elegans, Required genes, C. elegans embryo