Propagating Putative Prion States in Budding Yeast
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Date
2020
Authors
Evarts, Jacob
Garcia, David
Journal Title
Journal ISSN
Volume Title
Publisher
University of Oregon
Abstract
Prions have long been closely associated with fatal neurodegenerative diseases. Recent evidence suggests that prions provide an additional class of epigenetic mechanism that works at a rapid pace. From an evolutionary standpoint, the ability to change phenotypes without waiting for a genetic variance would be hugely beneficial in a high-stress environment. Using two known techniques for increasing de novo prion formation, protein overexpression, and environmental stressor, the Garcia Lab performed a large-scale screen across many RNA modifying enzymes in budding yeast. The initial analysis of the resulting growth curves suggests that putative prion-state induction could be a widespread epigenetic mechanism across yeast.
Description
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Keywords
Budding Yeast, Prions, RNA, Proteins, Computational Biology