Characterizing the impact of adversity, abuse, and neglect on adolescent amygdala resting-state functional connectivity

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dc.contributor.authorCheng, Theresa W.
dc.contributor.authorMills, Kathryn L.
dc.contributor.authorMiranda Dominguez, Oscar
dc.contributor.authorZeithamova, Dagmar
dc.contributor.authorPerrone, Anders
dc.contributor.authorSturgeon, Darrick
dc.contributor.authorFeldstein Ewing, Sarah W.
dc.contributor.authorFisher, Philip A.
dc.contributor.authorPfeifer, Jennifer H.
dc.contributor.authorFair, Damian A.
dc.contributor.authorMackiewicz Seghete, Kristen L.
dc.date.accessioned2021-01-15T00:07:50Z
dc.date.available2021-01-15T00:07:50Z
dc.date.issued2020
dc.description18 pagesen_US
dc.description.abstractCharacterizing typologies of childhood adversity may inform the development of risk profiles and corresponding interventions aimed at mitigating its lifelong consequences. A neurobiological grounding of these typologies requires systematic comparisons of neural structure and function among individuals with different exposure histories. Using seed-to-whole brain analyses, this study examined associations between childhood adversity and amygdala resting-state functional connectivity (rs-fc) in adolescents aged 11–19 years across three independent studies (N = 223; 127 adversity group) in both general and dimensional models of adversity (comparing abuse and neglect). In a general model, adversity was associated with altered amygdala rs-fc with clusters within the left anterior lateral prefrontal cortex. In a dimensional model, abuse was associated with altered amygdala rs-fc within the orbitofrontal cortex, dorsal precuneus, posterior cingulate cortex, and dorsal anterior cingulate cortex/anterior mid-cingulate cortex, as well as within the dorsal attention, visual, and somatomotor networks. Neglect was associated with altered amygdala rs-fc with the hippocampus, supplementary motor cortex, temporoparietal junction, and regions within the dorsal attention network. Both general and dimensional models revealed unique regions, potentially reflecting pathways by which distinct histories of adversity may influence adolescent behavior, cognition, and psychopathology.en_US
dc.identifier.citationTheresa W. Cheng, Kathryn L. Mills, Oscar Miranda Dominguez, Dagmar Zeithamova, Anders Perrone, Darrick Sturgeon, Sarah W. Feldstein Ewing, Philip A. Fisher, Jennifer H. Pfeifer, Damien A. Fair, Kristen L. Mackiewicz Seghete, Characterizing the impact of adversity, abuse, and neglect on adolescent amygdala resting-state functional connectivity, Developmental Cognitive Neuroscience, Volume 47, 2021, 100894, ISSN 1878-9293, https://doi.org/10.1016/j.dcn.2020.100894.en_US
dc.identifier.urihttps://doi.org/10.1016/j.dcn.2020.100894
dc.identifier.urihttps://hdl.handle.net/1794/25979
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsCreative Commons BY-NC-ND 4.0-USen_US
dc.subjectChildhood adversityen_US
dc.subjectChildhood maltreatmenten_US
dc.subjectAmygdalaen_US
dc.subjectResting-state functional connectivityen_US
dc.subjectAdolescenceen_US
dc.titleCharacterizing the impact of adversity, abuse, and neglect on adolescent amygdala resting-state functional connectivityen_US
dc.typeArticleen_US

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