Association between a Non-Invasive Assessment of Frailty and Vascular Dysfunction in Old Mice
| dc.contributor.author | Cole, Jazmin Amber | |
| dc.date.accessioned | 2020-09-29T21:59:50Z | |
| dc.date.available | 2020-09-29T21:59:50Z | |
| dc.date.issued | 2020 | |
| dc.description | 43 pages | |
| dc.description.abstract | Advancing age is characterized by not only an increased risk for cardiovascular diseases (CVDs), but also a decline in functional reserve and impaired adaptive capacity across multiple physiologic systems, also known as frailty. Impaired vascular function is a known contributor to CVDs and potentially has a role in increased frailty. In patients with overt disease, measures of frailty are related to vascular endothelial cell dysfunction. However, the relation between vascular endothelial function and frailty in a non-disease population is unknown. It is also unknown if dysfunction of a particular vascular bed is more closely related to frailty. This study aimed to correlate vascular dysfunction with age and frailty and examine possible mechanisms in genetically and environmentally identical mice. The major finding of this study is that frailty is correlated with age and mesentery artery endothelial cell dysfunction. The driver of this dysfunction appears to be oxidative stress and lower antioxidant enzyme expression. In contrast to mesentery arteries, middle cerebral artery endothelial dysfunction was not correlated with frailty index or age. These results suggest that frailty index could be a non-invasive marker of vascular impairment or improving mesentery artery health may be a possible way to reduce frailty in older adults. | en_US |
| dc.identifier.uri | https://hdl.handle.net/1794/25733 | |
| dc.language.iso | en_US | |
| dc.publisher | University of Oregon | |
| dc.subject | Human Physiology | en_US |
| dc.subject | Cardiovascular | en_US |
| dc.subject | Vascular Aginh | en_US |
| dc.subject | Aging | en_US |
| dc.subject | Gene Expression | en_US |
| dc.subject | Frailty | en_US |
| dc.title | Association between a Non-Invasive Assessment of Frailty and Vascular Dysfunction in Old Mice | |
| dc.type | Thesis/Dissertation |