Thiamine Deficiency in Cambodian Infants

dc.contributor.authorGallivan, Lauren Elizabeth
dc.date.accessioned2020-09-29T22:01:42Z
dc.date.available2020-09-29T22:01:42Z
dc.date.issued2020
dc.description48 pages
dc.description.abstractCambodian infants are at significant risk of malnutrition, and thiamine deficiency, in particular. This can put their survival at stake, but may also imperil the integrity of developing neural systems that support learning and cognitive/linguistic functioning. In this thesis I focused on the extent to which daily thiamine supplementation of Cambodian infants’ breast-feeding mothers during early infancy protects infants’ language-processing skill when measured at 6 months of age. 335 breast-feeding Cambodian mother/infant pairs were randomly assigned to one of four daily supplementation groups (placebo control, 1.2 mg, 2.4 mg, 10 mg) in a large-scale, double-blind, randomized-control trial. Infants’ language-processing skill was measured via a task indexing a previously well-documented tendency for infants to prefer Infant-Directed Speech (IDS) over Adult-Directed Speech (ADS), even when speech is presented in a non-native language. As a whole, the sample of 237 Cambodian 6-month-olds who completed the task displayed a systematic preference for IDS over ADS. Strikingly, however, the level of thiamine supplementation infants received displayed a dose-response relationship with the magnitude of their IDS preference, indicating that thiamine supplementation protects the integrity of language-focused neural systems.en_US
dc.identifier.urihttps://hdl.handle.net/1794/25747
dc.language.isoen_US
dc.publisherUniversity of Oregon
dc.subjectGeneral Scienceen_US
dc.subjectLanguage Developmenten_US
dc.subjectInfanten_US
dc.subjectMothereseen_US
dc.subjectThiamineen_US
dc.subjectMalnutritionen_US
dc.subjectSupplementationen_US
dc.subjectCambodiaen_US
dc.titleThiamine Deficiency in Cambodian Infants
dc.typeThesis/Dissertation

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