The Postural Affect on the Distribution of Microbubbles in the Lungs; A Model Study
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Intrapulmonary arteriovenous anastomoses, (IPAVAs) are pathways located in the lungs that provide an alternate route for blood to travel though. Blood that travels through IPAVAs may not participate in gas exchange. We know that these paths exist, but their exact location in the lungs is unknown. With the use of microbubbles and macroaggregates of albumin (MAA) research was done that attempted to determine the size and location of IPAVAs. My research specifically looked at the routes that microbubbles take when they enter into the lungs and how this may relate to the routes bubbles take in the lungs when the lung is upright or supine. The results of this study suggest that when a subject is lying on their back bubbles should be distributed evenly throughout the lungs. Conversely, when a subject is sitting upright the same amount of bubbles float towards the top of the lungs as travel to the bottom, despite differences in the distribution of blood flow.