MAGNETOELASIC SENSORS FOR THE REAL-TIME TRACKING OF MSC GROWTH
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Date
2022
Authors
Zhang, Sunny
Journal Title
Journal ISSN
Volume Title
Publisher
University of Oregon
Abstract
The cell therapeutics industry has grown significantly in the past decade; however, in adherent cell cultures, there is still a technological gap for a non-invasive, scalable, method of tracking cell-number and critical process parameters remotely and in real-time. Magnetoelastic sensors can be manipulated remotely with magnetic fields to monitor different physical, chemical, and biological parameters. Fabrication of these sensors can also be scaled into different sizes to be used in chemical and biological sensing, making them a promising prospect in tracking the growth of human-derived Mesenchymal stromal/stem cells (hMSCs) in real-time. In this study, we develop a sensing platform that uses magnetoelastic materials to monitor MSC growth/numbers in 2D in vitro cell cultures. Cultured MSCs are seeded onto a magnetoelastic sensor, which is then excited by an alternating magnetic field that causes the sensor to resonate and generate a magnetic flux. The basis for this research is supported by previous studies with magnetoelastic sensors that have shown the capability of measuring the cell numbers of L929 fibroblasts. This study intends to continue the development of the sensing platform for the purpose of remotely tracking MSC growth in real-time. The technology being developed will offer a more robust and scalable approach for monitoring and manufacturing stromal/stem cells in a consistent manner.
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Keywords
Magnetoelastic Sensors, MSC, Cell Tracking, Tracking System