The Role and Regulation of Vascular Endothelial Growth Factor in Heart Development
Loading...
Date
2014-06
Authors
Jones, Amy E.
Journal Title
Journal ISSN
Volume Title
Publisher
University of Oregon
Abstract
The most common birth defects are due to malformations that occur during the
development of the heart. The valves, trabeculae, and surrounding vasculature are all
targets for molecular mishaps that can lead to lethality and other severe consequences in
later life. The development of the various structures of the heart is complex and
composed of multiple steps that ultimately contribute to the formation of the organ
responsible for the distribution of blood and nutrients throughout the body.
Vascular Endothelial Growth Factor (VEGF) signaling is one of the pathways
involved in the formation of the various heart structures. This thesis presents the known
regulation and spatiotemporal roles of this pathway in an attempt to compile scattered
research done on the topic. In addition, new hypotheses are presented alongside updated
potential models to explain the dynamic roles ofVEGF signaling during development.
Furthermore, potential experiments and areas of future research are outlined to spur new
studies to further understand this signaling pathway and its interactions during heart
development.
Description
44 pages. A thesis presented to the Department of Biology and Human Physiology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Spring 2014.
Keywords
Heart valves, Trabeculation, Heart, Vascular endothelial, VEGF, Heart development