The Role and Regulation of Vascular Endothelial Growth Factor in Heart Development

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dc.contributor.authorJones, Amy E.
dc.date.accessioned2014-09-18T18:04:07Z
dc.date.available2014-09-18T18:04:07Z
dc.date.issued2014-06
dc.description44 pages. A thesis presented to the Department of Biology and Human Physiology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Spring 2014.en_US
dc.description.abstractThe most common birth defects are due to malformations that occur during the development of the heart. The valves, trabeculae, and surrounding vasculature are all targets for molecular mishaps that can lead to lethality and other severe consequences in later life. The development of the various structures of the heart is complex and composed of multiple steps that ultimately contribute to the formation of the organ responsible for the distribution of blood and nutrients throughout the body. Vascular Endothelial Growth Factor (VEGF) signaling is one of the pathways involved in the formation of the various heart structures. This thesis presents the known regulation and spatiotemporal roles of this pathway in an attempt to compile scattered research done on the topic. In addition, new hypotheses are presented alongside updated potential models to explain the dynamic roles ofVEGF signaling during development. Furthermore, potential experiments and areas of future research are outlined to spur new studies to further understand this signaling pathway and its interactions during heart development.en_US
dc.identifier.urihttps://hdl.handle.net/1794/18262
dc.language.isoen_USen_US
dc.publisherUniversity of Oregonen_US
dc.relation.ispartofseriesUniversity of Oregon thesis, Dept. of Biology and Human Physiology, Honors College, B.S., 2014;
dc.rightsAll Rights Reserved.en_US
dc.subjectHeart valvesen_US
dc.subjectTrabeculationen_US
dc.subjectHearten_US
dc.subjectVascular endothelialen_US
dc.subjectVEGFen_US
dc.subjectHeart developmenten_US
dc.titleThe Role and Regulation of Vascular Endothelial Growth Factor in Heart Developmenten_US
dc.typeThesis / Dissertationen_US

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