Theses & Dissertations

Albert-Galtier, Alexandre M'Enesti, Ana-Maria 2015-01-14T16:00:15Z 2015-01-14T16:00:15Z 2015-01-14 http://hdl.handle.net/1794/18754 The Theatre of the Absurd often has been considered the reflection of a deconstructionist gesture, a negation of the existent theatrical norms, therefore an end in itself without any prospect of possible alternatives or remedies. While this may be partially true, the entropy inherent to the absurd does not adhere to a mechanically formal posture; rather, the "purposeless wandering", in Eugène Ionesco's case, points, through humor (Ce formidable bordel), toward a longing for meaning, deeply rooted in the human being. This very longing is the crux of Ionesco's humanism. For him suffering (Le Roi se meurt), as the offshoot of the human being's finite condition and the affect that bonds the community, is intertwined with an unexplained feeling of wonderment--an opening to contemplation of the infinite. The merging of suffering and wonderment that suffuses Ionesco's textual and visual works presents the field in which his vision of a metaphysical humanism must find form. Art, in Ionesco's perspective, as the expression of being and the witness of its time (Rhinocéros), can be understood as a redemptive medium, a hope for humanism. Through the interplay of text (plays, reflections and short stories), image (drawings, gouaches and lithographs) and performance, this dissertation explores themes, imagery and structures that reflect Ionesco's paradoxical view on humanism. Thus, in light of interdisciplinary readings, I identify archetypal images recurrent in Ionesco's works and his subversive interpretation of these images as revelatory of the author-painter's inner search for meaning. This quest, which is the unifying principle throughout Ionesco's work, is revealed in themes spanning from the entropy of language (La Cantatrice chauve, Les Chaises) to the sacrificial act of substituting for the other (Maximilien Kolbe). In this ultimate act of testimony, Ionesco depicts Emmanuel Lévinas' ethics wherein the self becomes a "hostage" of the other, vulnerable at the encounter with the other. My analysis of Ionesco's humanism continues beyond his works with a reading of the historicized absurd and humanism in the works of two contemporary diasporic playwrights: Matéi Visniec and Saviana Stanescu. en_US University of Oregon All Rights Reserved. absurd Ionesco metaphysical humanism theatre visual arts A Painter of the Absurd: Reading Through and Beyond Eugène Ionesco's Humanism Electronic Thesis or Dissertation Ph.D. doctoral Department of Romance Languages University of Oregon

Berglund, Andrew Fierro Jr., Javier 2015-01-14T16:00:04Z 2015-01-14T16:00:04Z 2015-01-14 http://hdl.handle.net/1794/18752 In order for a human being to process complex thought, cells within the brain must communicate with each other in a very precise manner. The mechanisms which underlie the development of these connections, however, are poorly understood and thus require a thorough investigation. In this dissertation, we attempt to identify components involved in stabilizing synaptic contacts and the mechanisms by which synaptic proteins are trafficked to newly forming contact sites. Interestingly, we also identify a gene involved in the formation of the myotome. To identify proteins involved in stabilizing synaptic contacts, we characterized the function of 4.1B in developing zebrafish embryos. 4.1B is a scaffolding molecule involved in stabilizing protein complexes at sites of cell adhesion. We identified two 4.1B genes in the zebrafish genome, 4.1B-a and 4.1B-b, which are differentially expressed and have evolved divergent functions. 4.1B-a is expressed within the central nervous system, specifically within primary motor neurons. Knockdown studies show a reduction in the number of synapses and altered kinetics of touch evoked-responses, suggesting a role in synaptic stabilization. In contrast, 4.1B-b is primarily expressed in muscle cells. Knockdown of 4.1B-b results in severe muscle fiber disorganization as well as altered locomotor behaviors. Together, these data suggest the basic functions of 4.1B are evolutionarily conserved, with new roles described in the development of synapses and muscle fibers. To determine the mechanisms that underlie protein recruitment to newly forming synapses, we examined the recruitment of three distinct transport packets in the zebrafish spinal cord. During presynaptic assembly, we found synaptic vesicle protein transport vesicles preceded piccolo-containing active zone precursor transport vesicles, which in turn preceded synapsin transport vesicles. We identified the last transport packet as a unique and independent mechanism for the recruitment of synapsin, a protein involved in regulating the reserve pool of synaptic vesicles. Importantly, we found cyclin-dependent kinase 5 regulated the late recruitment of synapsin transport packets to synapses, thus identifying kinases as a key signaling molecule in the formation of synaptic contacts. Together, this work provides new insight into the mechanisms that underlie synaptogenesis. This dissertation includes both previously published and unpublished co-authored material. en_US University of Oregon All Rights Reserved. Developmental Neurobiology Synaptogenesis Zebrafish Development Glutamatergic Synapse Formation in Developing Zebrafish Embryos Electronic Thesis or Dissertation Ph.D. doctoral Department of Chemistry and Biochemistry University of Oregon

Vazquez, David Platt, Daniel 2015-01-14T15:59:55Z 2015-01-14T15:59:55Z 2015-01-14 http://hdl.handle.net/1794/18750 My dissertation examines critical engagements with the "new urbanist" movement in late 20th and early 21st century U.S. novels, including Karen Tei Yamashita's Tropic of Orange, Helena María Viramontes's Their Dogs Came with Them, and Colson Whitehead's Zone One. I argue that these novels reflect new urbanism's valorization of neighborhoods that are walkable, green, and diverse, even as they critique the movement's inattention to environmental injustice and the long history of urban rights movements. Moreover, I argue that contemporary fiction's engagement with new urbanism has driven formal and stylistic innovation in the novel. The "new urbanist novel," I argue, blends elements of the postmodern literary mode, such as metafiction and narrative fragmentation, with elements that are arguably anti-postmodern, such as representations of stable collective identity and utopian visions of organic urban community. en_US University of Oregon All Rights Reserved. Ecocriticism Environmental Justice New Urbanism Postmodernism Social Movements "A Strangely Organic Vision": Postmodernism, Environmental Justice, and the New Urbanist Novel Electronic Thesis or Dissertation Ph.D. doctoral Department of English University of Oregon