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Zarro, Elizabeth (University of Oregon, April , 2014)[more][less]Zarro, Elizabeth 2015-08-21T23:13:24Z 2015-08-21T23:13:24Z 2014-04 http://hdl.handle.net/1794/19358 52 pages. A thesis presented to the Product Design Department and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Fine Arts, Spring 2014. Pinico/a Shelves is the product of extensive biomimetic research and a product design senior studio with its focus on home-goods. With the use of biomimicry the product of this project remained innovative while also reducing the raw material usage and carbon emissions. Pinicola Shelves was able to fill an innate human need to have a closeness to nature through biomimicry. Inspired by Fomilopsis pinico/a, this shelving unit is ready to assemble by the user and can be flat-packed for shipping purposes. The product consists of one large dowel, and five stackable shelving trays secured by dowels. The unit follows the seven universal design principles which are a set of guidelines for designers to develop products that can be utilized by the majority of the population; exceeding the average user and bringing usability to those whom might be differently abled with limited mobility. The features that make this shelving unit more sustainable than those that precede it include: a large reduction of materials used, a physically lighter product, and a product that has flat-packing capabilities. en_US University of Oregon University of Oregon theses, Product Design Department, Honors College, B.F.A.;2014 Creative Commons BY-NC-ND 4.0-US Product design Biomimicry Bioinspired design Homegoods Furniture sustainable design Bio-inspired Product Design: The Study of Pinicola Shelves Thesis / Dissertation
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Peck, Mairin (University of Oregon, August , 2015)[more][less]Peck, Mairin 2015-08-21T20:31:32Z 2015-08-21T20:31:32Z 2015-08 http://hdl.handle.net/1794/19357 49 pages. A thesis presented to the Department of Uman Physiology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Arts, Summer 2015. The beneficial cardiovascular adaptations associated with endurance exercise are widely acknowledged, but the exact mechanisms mediating such adaptations are not well understood. Research has indicated that acute sustained postexercise vasodilation is induced by histamine receptor activation, and recent studies suggest that increased intramuscular histamine is responsible for this response. Currently, the specific exercise related factor or factors that trigger histamine release is unknown. Increased skeletal muscle temperature has been hypothesized as the key exercise condition that mediates histamine release; the current study is the first phase of an investigation that will ultimately address this hypothesis. This study examined the skeletal muscle temperature changes that occur during 60 minutes of single leg dynamic knee extension exercise at 60% of maximal work rate. The equilibration temperature specific to this exercise model was 39.15 ± 0.69 °C. The knowledge developed in this study will enable future studies to investigate the relationship between increased skeletal muscle temperature and histamine release. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Human Physiology Biology Muscle Temperature Histamine Temperature Exercise Skeletal Muscle Vasodilation Postexercise Temperature Changes in Human Skeletal Muscle during Single Leg Dynamic Knee Extension Exercise Thesis / Dissertation
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McMahan, Caitlin (University of Oregon, June , 2015)[more][less]McMahan, Caitlin 2015-08-13T18:59:02Z 2015-08-13T18:59:02Z 2015-06 http://hdl.handle.net/1794/19141 101 pages. A thesis presented to the Department of English and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Arts, Spring 2015. This thesis makes an attempt to track the progression of the social expectations placed on children and adults through J.M. Barrie's play, "Peter Pan," and various subsequent adaptations of that work. Spanning the length of approximately a century, I have compared the works of Barrie, both his play and his novel, to film adaptations from time periods which I believe to highlight pivotal moments in the evolution of Western culture, primarily those of England and the United States. Issues of gender roles, family structures, and the definition of the individual as a member of a community all contribute to the fashioning of society, both the young and the old. This work attempts to comment on the changes made to primary characters within the Peter Pan narrative which depict these social changes, reflecting on the audience's expectations of society, contemporary to that work. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US English Peter Pan Film Growing Up Adaptations Hook Disney P.J. Hogan The Flight From Neverland: Coming of Age Through a Century of Peter Pan Thesis / Dissertation
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Kales, Spencer (University of Oregon, June , 2015)[more][less]Kales, Spencer 2015-08-13T18:58:43Z 2015-08-13T18:58:43Z 2015-06 http://hdl.handle.net/1794/19140 123 pages. A thesis presented to the Department of Anthropology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Arts, Spring 2015. History is contentious by its nature. Researchers constantly question, challenge, and compete against each other in efforts to advance their own ideas, theories, and conclusions. History is also often unpleasant or disturbing. Humans have done – and continue to do – horrible things to one another. How are these difficult topics researched, written about, and represented to the public? The same event or time period can be interpreted numerous ways, with researchers examining different evidence and viewing the information through a variety of lenses. An event or period which one publication focuses on may be completely absent from another. These varying historical narratives are selectively incorporated into museums, where visitors come to learn and enjoy themselves. Museums mold the narratives in their exhibits through the selection of information they draw on, and the degree to which they address historical topics. This project is an investigation of the selection or creation of narratives in small, local museums, drawing on two case studies: the history of the Northern Paiute tribe in central Oregon museums, and the history of Rapa Nui represented in the Museo Padre Sebastián Englert (MAPSE) and around the island. The conclusions of the project reveal the relative absence of information relating to difficult and unpleasant topics in these cultures' histories, the sanitization of historical narrative, and the complex relationship between indigenous sovereignty, academia, modern indigenous communities, and the sociopolitical repercussions. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Anthropology History Museums Easter Island Rapa Nui Northern Paiute Narrative Representation of Contested Narratives in the Anthropological Museum: Case Studies on Rapa Nui (Easter Island) and the Northern Paiutes of Central Oregon Thesis / Dissertation
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Khalifa, Muhammad (University of Oregon, September , 2014)[more][less]Khalifa, Muhammad 2015-08-13T18:56:58Z 2015-08-13T18:56:58Z 2014-09 http://hdl.handle.net/1794/19139 52 pages. A thesis presented to the Department of Chemistry, Biochemistry, and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Fall 2014. This project describes an efficient method for the direct preparation of N-substituted aryl amidines from nitriles and primary amines. The method employs activation of amines by a strong base and provides greater access to a pharmaceutically relevant functional group. The creation of functionalized amidines and salient amidine-containing moieties via the newly described route was explored. This synthetic approach tolerates deactivated nitriles, nitriles with competing nucleophilic aromatic substitution sites, and aryl amines. Serial amidine formation is also possible, leading to new routes for the creation of tetrahydropyrimidines, benzimidazoles, and bis-amidines. The method described herein features superior yields, improved material and time economy, and greater starting material compatibility compared to other established routes of amidine synthesis. Additionally, this project led to the creation and characterization of six compounds hitherto undescribed in the literature. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Organic Chemistry Biochemistry Synthesis Pharmaceutical Chemistry Amidines Methods Amines Nitriles Synthesis of N-Substituted Aryl Amidines by Strong Base Activation of Amines Thesis / Dissertation
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Rheingold, Charlotte (University of Oregon, June , 2015)[more][less]Rheingold, Charlotte 2015-08-13T18:56:39Z 2015-08-13T18:56:39Z 2015-06 http://hdl.handle.net/1794/19138 48 pages. A thesis presented to the Department of Comparative Literature and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Arts, Spring 2015. The 19th century marked changes for ballet at the Paris Opera that contributed to its development as a well-regarded independent genre. One such change was the emergence of the librettist who wrote original narratives for ballets, inherently connecting the silent art of ballet with the written word. From choreographers and composers to set designers, many involved in the production of the ballet tended to use the libretto to render the narrative onstage. Spectators, in turn, relied on the libretto to comprehend the narrative content of the dance, whether watching it in the theater or reading the story on its own. In either of these cases, the libretto linked the world of the stage and that of the text, generating meaning across various interrelated media. This thesis delineates the types of language used to appeal to these different constituencies of readers, and it explains how the libretto uses these varying narrative registers to fulfill its role as a hybrid text, intended for both pre- and post-production readings. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Ballet Libretto Ballet Libretto Theophile Gautier 19th Century Writing for the Legs: The Role of the Libretto in 19th Century Ballet Thesis / Dissertation
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Kim, Nayeon (University of Oregon, June , 2015)[more][less]Kim, Nayeon 2015-08-13T18:56:26Z 2015-08-13T18:56:26Z 2015-06 http://hdl.handle.net/1794/19137 72 pages. A thesis presented to the Department of History and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Arts, Spring 2015. The year 1973 brought General Augusto Pinochet to power through a coup d’état that disrupted and transformed Chilean democracy. This investigation examines the first seven years of junta rule, during which Pinochet adapted various strategies to gain and manage his legitimacy. From 1973 to 1974, he violently repressed dissidents and embraced a discourse of democracy to convince Chileans of his mandate and capacity to protect them from communist takeover. A climate of fear prevailed throughout society, and within two years, organized opposition was either exterminated, exiled, or retreated, which created space for Pinochet to exert his authority. The junta’s confronted new pressures in 1975 with the Church Committee investigations and a highly publicized assassination in 1976 that fractured its alliance with the US government. The military regime faced high political costs for its extreme use of force, and Pinochet struggled to defend his right to rule to the international community that condemned his human rights violations. He distanced himself from mass repression and instead prepared the way for a Constitution that would centralize his power, while pushing back on a strained US government to uphold its commitment to their alliance. This narrative explores how Pinochet struggled to maintain international standing when external forces kept his legitimacy in tension and prioritized human rights as a condition for democracy during this era. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US History Chile Dictatorship Repression Cold War Augusto Pinochet U.S. Intervention From Coup to Constitution: Repression, Legitimacy, and Human Rights in Pinochet’s Chile (1973-1980) Thesis / Dissertation
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McVeety, Kelsie (University of Oregon, June , 2015)[more][less]McVeety, Kelsie 2015-08-13T18:56:05Z 2015-08-13T18:56:05Z 2015-06 http://hdl.handle.net/1794/19136 62 pages. A thesis presented to the Department of Anthropology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Spring 2015. HIV/AIDS continues to be a widespread epidemic that is currently treated with immunotherapies that target the viral mechanisms, leaving room for the evolution of resistant strains. Most research into novel therapies that target the human immune response investigates the mechanisms that leave humans vulnerable to HIV infection. However, there is much to be gained by examining nonhuman primate species whose immune systems can naturally survive with high levels of replication of a related lentivirus, simian immunodeficiency virus (SIV), without the result of chronic immune activation or viral resistance. These species are known as nonprogressors, and by investigating an adaptive explanation for their tolerance of SIV this project sought to connect the evolutionary history of these species to variation in immune response to SIV, with the intent of identifying target genes and molecular pathways for future medical intervention and deepening our knowledge of how natural selection and coevolution with lentiviruses has shaped primate immune responses in general. Evolutionary genetic methods were used to test for positive selection, convergent evolution, and variants that distinguish nonprogressors from progressors in the protein-coding and cis-regulatory regions of four genes (CASP1, CD38, EEF1D, and SOCS1) differentially expressed in progressors and nonprogressors during the chronic phase of infection (Bosinger et. al. 2009). Results indicate these genes are largely conserved in these primates and have experienced negative selection. Furthermore, nonprogressors do not share derived variants in the promoter regions. Future research should look to test the functional significance of distinguishing polymorphisms in regulatory and protein-coding regions of genes differentially expressed in nonprogressors and progressors. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Molecular Anthropology Simian Immunodeficiency Virus SIV Human Immunodeficiency Virus Progressor Nonprogressor Bioinformatics Immunology Investigating an adaptive explanation for nonprogressor immune responses to SIV Thesis / Dissertation
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Klas, Rachel (University of Oregon, June , 2015)[more][less]Klas, Rachel 2015-08-13T18:44:08Z 2015-08-13T18:44:08Z 2015-06 http://hdl.handle.net/1794/19135 29 pages. A thesis presented to the Department of Human Physiology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Spring 2015. Concussion, a brain trauma resulted from linear or rotational acceleration to the head, represents a majority of the traumatic brain injuries (TBI) sustained each year. To understand if there are recovery differences between males and females post-concussion, this research examined males and females with matched controls for two months following the injury. In this study, a 3-dimensional motion analysis system was used to observe the trajectory of 29 anatomical locations in order to determine the peak anterior velocity of each subject’s center of mass (COM, the point where the mass is equally distributed) and the medial-lateral COM sway. Symptom severity was assessed based on a 22-symptom inventory and a scale similar to the Likert scale for each symptom (ranking each symptom from 0-6). A three-way analysis of variance, or ANOVA, was performed to analyze the data in order to determine the effect of concussion, sex (male and female), time (72 hour, one week, two week, one month, and two month post-injury), and the interactions between these independent variables. It was revealed that males and females do not objectively differ in terms of the peak anterior COM velocity or COM medial-lateral displacement across the 2-month study, but that females reported more severe symptoms than males. The findings suggest that subjects of both sexes follow the same general gait balance recovery trends and that both sexes report heightened symptoms for at least two months after experiencing a concussion. Across all time points, females reported more symptoms than males, so either males are under-reporting their symptoms or females are experiencing more symptoms than males. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Concussion Recovery Male/Female Concussion Gait Balance Control Symptom Reporting Center of Mass Recovery Brain Trauma Differences in functional recovery following concussion between males and females Thesis / Dissertation
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Kleck, Emma (University of Oregon, June , 2015)[more][less]Kleck, Emma 2015-08-13T18:43:54Z 2015-08-13T18:43:54Z 2015-06 http://hdl.handle.net/1794/19134 44 pages. A thesis presented to the Department of Human Physiology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Spring 2015. Type 1 diabetes mellitus (DM1) has had a growing incidence over the past decade. This autoimmune disease is characterized by the destruction of beta cells in the pancreas, which makes the individual unable to produce insulin, a hormone required for glucose use in the cells. DM1 patients must check their blood glucose levels many times throughout the day, and administer a carefully calculated amount of synthetic insulin to cover food and maintain a target range of blood glucose levels. The closed-loop system is a compilation of DM1 control devices that calculates the correct amount of insulin (and in the case of a bi-hormonal system, glucagon) needed to maintain a target range of blood glucose readings. This thesis seeks to determine whether it is necessary for an exercise announcement option to be programmed into the algorithm so that the system can prevent hypoglycemia during and after exercise. It was found that using the closed loop with an exercise announcement is no more efficient at preventing hypoglycemia during and after exercise than a closed loop system without an exercise announcement or an open loop system (p=0.57 and 0.55, respectively). However, it is important to note that these results are only preliminary results of the Artificial Pancreas Control (APC) study in progress at Oregon Health and Sciences University; this thesis will present results from the first seven subjects of the APC study. Hardware errors, failed infusion sites, and early termination of individual subject studies make for a small sample size, and thus insignificant results. However, closed loop technology is promising, and once the APC study is completed it will act as a guide for future research in the field. Artificial pancreas technology is ever moving forward, and will eventually create a device or system that allows type 1 diabetics to live without constantly thinking of diabetes care and blood glucose control. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Closed-loop Technology Human Physiology Type 1 Diabetes Exercise Bi-Hormonal Insulin Glucagon Artificial Pancreas Hypoglycemia The Efficacy of a Bi-hormonal Closed-loop System at Preventing Hypoglycemia during and after Exercise Thesis / Dissertation
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Peralta, Joaquin (University of Oregon, June , 2015)[more][less]Peralta, Joaquin 2015-08-13T18:43:36Z 2015-08-13T18:43:36Z 2015-06 http://hdl.handle.net/1794/19133 47 pages. A thesis presented to the Department of General Science and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Spring 2015. The bilingual advantage hypothesis proposes that the experience of processing multiple languages affords an individual with mental resources that can extend beyond the domain of language, namely in executive control. Although various studies have found evidence in support of the bilingual advantage hypothesis, it is not without controversy, as there are also studies that provide evidence against such an advantage. This study explored a novel way of testing the bilingual advantage hypothesis, utilizing rates of mind wandering during an anti-saccade task as a measure of executive control. Although bilingual participants reported lower rates of mind wandering than monolingual participants, no bilingual advantage was found in anti-saccade task performance or working memory capacity measures. Bilingual group anti-saccade task performance was not affected by increased rates of mind wandering, suggesting that some difference in the executive control system exists, but developments in objective measures of mind wandering are required to further examine this possible difference. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Psychology Bilingual Mind Wandering Advantage Executive Attention Inhibition anti-saccade Testing the Bilingual Advantage Hypothesis: An Individual Differences Study on Rates of Mind Wandering Thesis / Dissertation
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Lanning, Amelia (University of Oregon, June , 2015)[more][less]Lanning, Amelia 2015-08-13T18:43:18Z 2015-08-13T18:43:18Z 2015-06 http://hdl.handle.net/1794/19132 35 pages. A thesis presented to the Department of Human Physiology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Spring 2015. Fatigue can be affected by several sex-related factors and the purpose of this study was to investigate those differences associated with maximal-effort isotonic contractions of the plantar flexors. The criterion measure of fatigue here was reductions in instantaneous peak power. It was hypothesized that males would fatigue more than females and this was supported as peak power was reduced in males by 34% and by only 22% for females at the end of the fatigue task. Novel aspects of this study include the sex-based investigation of fatiguing isotonic plantar flexor contractions and the inclusion of rate of torque development and rate of velocity development as factors that may be contributing to the decreases in production of power during fatigue tasks. Overall, this study shows that males are more fatigable during dynamic contractions of the plantar flexors. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Medicine Health Human Physiology Sex-related Fatigue Plantar Flexors Isotonic Dynamic Sex-related Differences of Fatigability during Isotonic Concentric Contractions of the Plantar Flexors in Humans Thesis / Dissertation
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Metzler, Paul (University of Oregon, December , 2014)[more][less]Metzler, Paul 2015-08-13T18:43:04Z 2015-08-13T18:43:04Z 2014-12 http://hdl.handle.net/1794/19131 43 pages. A thesis presented to the Department of Environmental Studies and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Arts, Fall 2014. Large patches (20-40 meters wide) of threatened Kincaid’s Lupine, Lupinus oreganus Heller, (host plant to endangered Fender’s Blue butterfly Icaricia icarioides fenderi Macy) exhibit a striking ring-like pattern of density suggestive of central die-back, in which there is a less dense outer zone, a denser middle zone, and a less dense center zone. To determine what might be causing this pattern, different zones were tested for seed germination, and the plants were analyzed for pathogen and herbivore damage, carbon and nitrogen content, and reproduction. Total germination and growth of the germinants did not significantly vary across zones or with plant density. Herbivory types and nitrogen levels were greater in the less dense outer zones of the patches. Flowering stems per leaf were more abundant in the denser middle zone. Kincaid’s lupine displays spatially explicit stoichiometric and herbivory patterns similar to those seen in other lupines, in which leaves in the less dense outer zone (margin) are more nutrient rich and receive greater herbivore damage. However, the less dense center zone had less damage from herbivory, implying that herbivory is not strictly density dependent, but instead depends on zone. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Ecology Wildlife Kincaid's Lupine Fender's Blue Butterfly Upland Prairie Stoichiometry Central Die-Back Density Investigations into the Spatial Growth Patterns of Kincaid's Lupine Thesis / Dissertation
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Lantz, Tyler (University of Oregon, June , 2015)[more][less]Lantz, Tyler 2015-08-13T18:42:47Z 2015-08-13T18:42:47Z 2015-06 http://hdl.handle.net/1794/19130 56 pages. A thesis presented to the Department of Chemistry, Biochemistry, and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Spring 2015. The thylakoid membrane is the site of the light reactions of photosynthesis and is the destination for many integral membrane proteins that are involved in photosynthesis. My research aims to elucidate the mechanisms that target chloroplast-encoded proteins to the thylakoid membrane. Previous studies have revealed three separate pathways by which nuclear-encoded proteins are targeted to the thylakoid membrane, each of which evolved from secretion systems in the cyanobacterial ancestor. Plastid-encoded proteins are hypothesized to use these pathways to integrate into the thylakoid membrane as well. By profiling ribosomes in separated soluble and membrane fractions, the Barkan lab showed that many plastid mRNAs are translated on ribosomes that are anchored to the thylakoid membrane, and that the proteins encoded by these mRNAs are inserted into the thylakoid co-translationally. I conducted partitioned ribosome profiling experiments on maize mutants that lack each of the three thylakoid membrane translocon machineries to reveal which thylakoid targeted proteins are excluded from co-translational membrane integration in these specific mutants. I found that the loss of certain translocon machinery had differential effects on the cotranslational targeting of plastid-encoded thylakoid membrane proteins. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Plant Biology Chloroplast Thylakoid Protein Co-translational Membrane Translocon Elucidating Mechanisms that Direct Chloroplast Encoded Proteins to the Thylakoid Membrane Thesis / Dissertation
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Leamon, Benjamin Palsa (University of Oregon, June , 2015)[more][less]Leamon, Benjamin Palsa 2015-08-13T18:42:19Z 2015-08-13T18:42:19Z 2015-06 http://hdl.handle.net/1794/19129 43 pages. A thesis presented to the Department of Geography and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Spring 2015. This research seeks to explore how the physical spaces of food consumption are changing in urban contemporary China, and examine how ideas of China’s past and future are mobilized in the discourse surrounding eating and food consumption. Finally the interactions between these physical spaces and the construction of discourses of food hygiene and purity are discussed. These questions are explored through a variety of popular and academic sources. In seeking to answer these questions, I focused on the use of hygiene discourse to marginalize street food vendors, and promote as friendly and comfortable the physical spaces of fast food restaurants, as well as the commodification of China’s past in Cultural Revolution-themed restaurants. Additionally, I examine the ways in which certain forms of sociality are fostered through and encouraged by the designed spaces of food consumption. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Geography Food Consumption China Food Urban Food Studies Contemporary China Consumption Spaces of Urban Food Consumption in Contemporary China Thesis / Dissertation
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Lerner, Kimberly (University of Oregon, June , 2015)[more][less]Lerner, Kimberly 2015-08-13T18:41:41Z 2015-08-13T18:41:41Z 2015-06 http://hdl.handle.net/1794/19128 45 pages. A thesis presented to the Department of Biology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Spring 2015. Usher syndrome is the main cause of hereditary deaf-blindness. Patients diagnosed with Usher syndrome experience hearing loss and progressive blindness due to photoreceptor degeneration over several decades. The most common form of Usher syndrome, type 2A, is caused by mutations in the USH2A gene, which encodes the large protein Usherin. In this study, I characterized three different mutations affecting distinct regions of the zebrafish ush2a gene. In these mutant backgrounds, I studied the co-localization of other proteins known to interact with Usherin to test whether the loss of the normal Usherin protein disrupted localization of these other proteins. In humans, photoreceptor cell death takes place over many years, causing slow, progressive vision loss. The USH2A mouse model of Usher syndrome has a mild retinal phenotype compared to the degree of vision loss that human patients experience, perhaps due in part to their shorter lifespan. Zebrafish, similarly, have a much shorter lifespan than humans, so we devised a system that would challenge the retina with increased levels of light in an effort to accelerate the rate of photoreceptor damage. These studies have established a functional zebrafish model of USH2A induced Usher syndrome, which will provide researchers with a valuable tool for investigating treating the functional role of Usherin in vision and hearing, as well as providing a model for which to test new treatment options. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Biology Neuroscience Zebrafish Usher Syndrome Deaf Blind Using Zebrafish Models of Usher Syndrome Type 2A to Investigate Retinal Cell Function and Survival Thesis / Dissertation
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Decision-Making in the NBA: The Interaction of Advanced Analytics and Traditional Evaluation MethodsMills, Jonathan (University of Oregon, June , 2015)[more][less]Mills, Jonathan 2015-08-13T18:30:50Z 2015-08-13T18:30:50Z 2015-06 http://hdl.handle.net/1794/19127 129 pages. A thesis presented to the Lundquist College of Business and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Spring 2015. Decision-making in the National Basketball Association (NBA) occurs in the three general contexts of player evaluation, team evaluation, and roster construction. This thesis will explore the interaction of two primary methods of evaluating basketball—“advanced analytics” and “traditional evaluation methods”—that must be integrated together to reduce risk in decision-making and achieve competitive advantage. “Advanced analytics” does not have a precise definition, but can broadly be defined in this thesis as “insights gained from quantitative data analysis about basketball.” “Traditional evaluation methods” include any form of observation, such as on-site scouting, live coaching, and game film analysis. Through an interview and survey protocol, this thesis explores methods for quantifying human intangibles, the role of “gut instinct,” NBA organizational structures, as well as the specific strategies and tools in place for key decision-makers to balance all available information. The findings of this thesis are that NBA organizations should formalize their decision-making processes with repeatable strategies and specific tools that align with the strategic plan and vision of the organization, in order to maximize team performance and pursue NBA championships. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Basketball Operations Sports Advanced Analytics Traditional Evaluation Decision-Making Basketball Operations NBA National Basketball Association Decision-Making in the NBA: The Interaction of Advanced Analytics and Traditional Evaluation Methods Thesis / Dissertation
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Moniz, Camille (University of Oregon, June , 2015)[more][less]Moniz, Camille 2015-08-13T18:30:29Z 2015-08-13T18:30:29Z 2015-06 http://hdl.handle.net/1794/19126 36 pages. A thesis presented to the Department of Psychology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Arts, Spring 2015. Mother-infant attachment has been linked to important social-emotional outcomes later in life. Disorganized attachment, a style where the caregiver is a source of fear, is particularly detrimental. The current study attempts to determine whether or not depression, childhood trauma, or the interaction of the two are predictive of two scales that in turn predict future attachment. We hypothesized that mothers who have experienced trauma and/or depression would label more infant faces as angry and fewer as sad and would also report more maternal helplessness and fear of their child. A sample of 44 new mothers was surveyed when their infants were 12 and 24 weeks as a part of a longitudinal study. Linear regression analyses revealed that postnatal depression, history of abuse or the interaction of the two were not predictive of maternal endorsements of fewer sad and more angry labels or maternal helplessness or fear. Implications for early identification and prevention of attachment disorganization are discussed. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Psychology Attachment Depression Trauma Early Predictors Sadness Anger Postpartum Impacts of Depression and Trauma on Predictors of Future Infant-Caregiver Attachment Thesis / Dissertation
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Pratt, Jordan E. (University of Oregon, June , 2015)[more][less]Pratt, Jordan E. 2015-08-13T18:30:12Z 2015-08-13T18:30:12Z 2015-06 http://hdl.handle.net/1794/19125 102 pages. A thesis presented to the Department of Anthropology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Arts, Spring 2015. Climate change dramatically transforms the ecological zones that humans call home. Historically the northern Great Basin region of eastern Oregon provides an ideal case in which to study human adaptation to climate change because in this region, the Pleistocene-Holocene transition that brought the first people into the region, was followed by multiple smaller shifts in climate that influenced people’s ecological adaptations to the region. The early Middle Holocene of around 8,000 – 4,000 calendar years ago (cal. B.P.) provided one of these warming periods, in which the regional environment became much drier and more arid. One of the few types of material culture that have reliably been dated to the early Middle Holocene in the northern Great Basin are Northern Side-notched points, a type of atlatl dart point dated to circa 7,000-4,000 cal. BP. In this paper, Northern Side-notched points collected by the Bureau of Land Management Burns BLM District and UO Museum of Natural and Cultural History’s Archaeological Field School are analyzed to establish a rigorously objective classification for such projectile points found in eastern Oregon. BLM site reports are analyzed to determine significant site characteristics that are then compared to Northern Side-notched site characteristics as previously determined by John Fagan in 1974. Finally, ArcGIS is used to geospatially analyze the distribution of the projectile points throughout the Burn’s BLM District compared to known obsidian sources. By analyzing the distribution of projectile points and movement of materials across the landscape, as well as site attributes, insights can be made into prehistoric mobility and settlement patterns. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Anthropology Archaeology Northern Great Basin Northern Side-notched Geospatial Analysis Mobility Patterns Middle Holocene Altithermal Climatic and Cultural Change in the Northern Great Basin: A Geospatial Analysis of Northern Side-notched Projectile Points from the Burns Bureau of Land Management District Thesis / Dissertation
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Moore, Hanna (University of Oregon, June , 2015)[more][less]Moore, Hanna 2015-08-13T18:06:52Z 2015-08-13T18:06:52Z 2015-06 http://hdl.handle.net/1794/19124 60 pages. A thesis presented to the Department of Biology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Spring 2015. The process of speciation is integral to producing and maintaining the great biodiversity of life on Earth; yet the underlying mechanisms of reproductive isolation remain largely a mystery. The widely accepted Bateson-Dobzhansky-Muller model cites the accumulation of intrinsic post-zygotic isolating mechanisms as the barrier to reproduction between two species. However, the characteristics of such accumulated incompatibilities are complex and varied and thus challenge our mechanistic understanding of the process of speciation. Using four Caenorhabditis populations, three geographically separate strains of C. remanei, and one strain of closely related C. latens, a multiple cross analysis of parental, F1, and F2 fitness levels was conducted to address these details of speciation, particularly when comparing standing within species incompatibility to incompatibility developed between species. Pairing the analysis of phenotypic measures of fitness and genetic incompatibility with a Mendelian Inheritance model presents compelling evidence of deleterious epistatic interaction in the between species crosses as well as within species crosses. These results indicate that markers of incipient speciation are quantifiably present in otherwise compatible populations of the same species. en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Speciation Biology Incompatibility C. ramanei Haldane's Rule Bateson-Dobzhansky-Muller Fitness Species Nematodes Incompatibility and Speciation Within and Between Species Thesis / Dissertation
