Abstract:
Previous studies have indicated that sustained post-exercise vasodilation is mediated by the activation of histamine receptors, but the specific signal responsible for driving the release of histamine in response to exercise remains unknown. Tissue manipulation and vibration have been hypothesized to be key mediators of this histamine release. In order to test this and related hypotheses, skeletal muscle blood flow in response to passive limb movement must be measured. This study compared two methodologies for doing so: Doppler ultrasound and near infrared spectroscopy-indocyanine green (NIRS-ICG). A low correlation (rratio = .238, rpercent difference = .278) between methods was found. However, clear changes in blood flow were observed through visual analysis of graphical representations of individual subject data. The knowledge developed in this study will enable future investigation of the relationship between passive limb movement and histamine through the measurement of regional skeletal muscle blood flow.
Description:
42 pages. A thesis presented to the Department of Human Physiology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science, Spring 2017