Browsing Chemistry Theses and Dissertations by Subject "Biochemistry"

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  • Auto-Regulation of the MBNL1 Pre-mRNA 
    Gates, Devika P., 1984- (University of Oregon, 2011-06)
    Muscleblind-like 1 (MBNL1) is a splicing factor whose improper cellular localization is a central component of myotonic dystrophy (DM). In DM, the lack of properly localized MBNL1 leads to mis-splicing of many pre-mRNAs. ...
  • Autoinhibition and ultrasensitivity in the Galphai-Pins-Mud spindle orientation pathway 
    Smith, Nicholas Robert, 1981- (University of Oregon, 2010-09)
    Protein-protein interaction networks translate environmental inputs into specific physiological outputs. The signaling proteins in these networks require regulatory mechanisms to ensure proper molecular function. Two common ...
  • Boron in Disguise: Towards BN Biomimics 
    Abbey, Eric Ryan, 1980- (University of Oregon, 2011-09)
    Chemists have long recognized the potential of the BN bond to mimic CC double bonds in aromatic systems. Phenyl and indole are two of the most important arenes in natural systems, as well as medicine, applied chemistry, ...
  • The chemistry of 1,2-dihydro-1,2-azaborine and nitrated lipids 
    Marwitz, Adam John Von, 1981- (University of Oregon, 2010-09)
    1,2-Dihydro-1,2-azaborine is a six-membered aromatic heterocycle that is related to the quintessential aromatic molecule, benzene, via the replacement of a CC fragment in benzene with an isoelectronic BN bond-pair. Like ...
  • Drosophila non-muscle myosin II bipolar filament formation: Importance of charged residues and specific domains for self-assembly 
    Ricketson, Derek Lee, 1980- (University of Oregon, 2009-06)
    Non-muscle myosin II generates contractile forces for processes such as cytokinesis, motility, and polarity. Contractility requires assembly of myosin molecules into bipolar mini-filaments through electrostatic interactions ...
  • In vitro and in cellulo interactions of platinum and ruthenium anticancer metallodrugs with RNA 
    Hostetter, Alethia A., 1981- (University of Oregon, 2011-03)
    Since its approval by the FDA in 1978 cisplatin (cis-diamminedichloroplatinum(II)) has revolutionized the treatment of several cancer types, particularly testicular cancer which now has a cure rate greater than 90%. Following ...
  • Mitochondrial dynamics and optical conformation changes in DsRed as studied by fourier imaging correlation spectroscopy 
    Senning, Eric Nicolas, 1978- (University of Oregon, 2009-09)
    Novel experiments that probe the dynamics of intracellular species, including the center-of-mass displacements and internal conformational transitions of biological macromolecules, have the potential to reveal the complex ...
  • Molecular Evolution of the Guanylate Kinase Domain 
    Anderson, Douglas (University of Oregon, 2015-01-14)
    The evolution of novel protein functions and protein families is a fundamental question within both evolutionary biology and biochemistry. While many gene families follow predictable patterns of molecular tinkering, many ...
  • Platinum coordination to RNA 
    Chapman, Erich G., 1984- (University of Oregon, 2010-12)
    Since discovery of its biological effects in the late 1960's, cisplatin (cis-diamminedichloroplatinum( II)) has become one of the most broadly-prescribed cancer drugs in use today. A majority of efforts to understand the ...
  • The regulation of alternative splicing associated with Myotonic Dystrophy 
    Warf, Michael Bryan (University of Oregon, 2009-09)
    Myotonic Dystrophy (DM) is a genetic disorder with multisystemic symptoms that is caused by expression (as RNA) of expanded repeats of CTG or CCTG in the genome. It is hypothesized that the protein MBNL1 (M[barbelow]uscl ...

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